D-3-羟基[3-¹⁴C]丁酸在泌乳大鼠乳腺体内用于脂肪生成的情况。
Utlization of D-3-hydroxy[3-14C]butyrate for lipogenesis in vivo in lactating rat mammary gland.
作者信息
Robinson A M, Williamson D H
出版信息
Biochem J. 1978 Nov 15;176(2):635-8. doi: 10.1042/bj1760635.
Abstract
Incorporation of D-3-hydroxy[3-14C]butyrate into lipid in vivo suggests that lactating mammary gland is a major site of ketone-body utilization. The incorporation decreases in short-term insulin deficiency (2h) and on starvation (24h), but increases again on refeeding (2h). The activity of cytosolic acetoacetyl-CoA synthetase parallels the changes in nutritional state, but is not affected by short-term insulin deficiency.
摘要
体内将D-3-羟基[3-¹⁴C]丁酸掺入脂质表明，泌乳乳腺是酮体利用的主要部位。在短期胰岛素缺乏（2小时）和饥饿（24小时）时，掺入量减少，但在重新喂食（2小时）时又会增加。胞质乙酰乙酰辅酶A合成酶的活性与营养状态的变化平行，但不受短期胰岛素缺乏的影响。
相似文献
1
Utlization of D-3-hydroxy[3-14C]butyrate for lipogenesis in vivo in lactating rat mammary gland.D-3-羟基[3-¹⁴C]丁酸在泌乳大鼠乳腺体内用于脂肪生成的情况。
Biochem J. 1978 Nov 15;176(2):635-8. doi: 10.1042/bj1760635.
2
The utilization of ketone bodies by the interscapular brown adipose tissue of the rat.大鼠肩胛间棕色脂肪组织对酮体的利用。
Biochim Biophys Acta. 1981 Oct 23;666(1):127-32. doi: 10.1016/0005-2760(81)90098-9.
3
Tissue-specific effects of starvation and refeeding on the disposal of oral [1-14C]triolein in the rat during lactation and on removal of litter.饥饿和再喂养对哺乳期大鼠口服[1-14C]甘油三酯代谢及幼崽清除的组织特异性影响。
Biochem J. 1988 Sep 1;254(2):539-46. doi: 10.1042/bj2540539.
4
Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state.胰岛素和胰高血糖素对泌乳大鼠乳腺脂肪生成的体内调节。胰岛素在转变为饥饿状态过程中的作用及作用位点。
Biochem J. 1984 Oct 15;223(2):345-51. doi: 10.1042/bj2230345.
5
Evidence for a role of insulin in the regulation of lipogenesis in lactating rat mammary gland. Measurements of lipogenesis in vivo and plasma hormone concentrations in response to starvation and refeeding.胰岛素在泌乳大鼠乳腺脂肪生成调节中作用的证据。饥饿和再喂养后体内脂肪生成及血浆激素浓度的测定。
Biochem J. 1978 Oct 15;176(1):343-6. doi: 10.1042/bj1760343.
6
The regulation of lipogenesis in vivo in the lactating mammary gland of the rat during the starved-refed transition. Studies wtih acarbose, a glucosidase inhibitor.饥饿-再喂养过渡期大鼠泌乳乳腺体内脂肪生成的调节。使用阿卡波糖（一种葡萄糖苷酶抑制剂）的研究。
Biochem J. 1987 Feb 15;242(1):235-43. doi: 10.1042/bj2420235.
7
Biosynthesis of lipids from (2-14C)acetate and D(-)-beta-hydroxy(1,3-14C)butyrate by mammary cells from bovine and rat.牛和大鼠乳腺细胞利用（2-¹⁴C）乙酸盐和D（-）-β-羟基（1,3-¹⁴C）丁酸盐合成脂质。
Biochim Biophys Acta. 1970 Jun 9;210(1):28-38. doi: 10.1016/0005-2760(70)90058-5.
8
Role of pyruvate dehydrogenase and insulin in the regulation of lipogenesis in the lactating mammary gland of the rat during the starved-refed transition.饥饿-再喂养过渡期大鼠泌乳乳腺中丙酮酸脱氢酶和胰岛素在脂肪生成调节中的作用
Biochem J. 1981 Jun 15;196(3):831-7. doi: 10.1042/bj1960831.
9
Short-term dietary regulation of lipogenesis in the lactating mammary gland of the rat.大鼠哺乳期乳腺脂肪生成的短期饮食调节
Adv Enzyme Regul. 1983;21:135-45. doi: 10.1016/0065-2571(83)90012-2.
10
Effects of inhibition of protein synthesis by cycloheximide on lipogenesis in mammary gland and liver of lactating rats.放线菌酮抑制蛋白质合成对泌乳大鼠乳腺和肝脏脂肪生成的影响。
Biochem J. 1982 May 15;204(2):417-23. doi: 10.1042/bj2040417.
引用本文的文献
1
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells.β-羟基丁酸代谢的另一条途径支持癌细胞中胞质乙酰辅酶A的合成。
Nat Metab. 2025 Sep 8. doi: 10.1038/s42255-025-01366-y.
2
Ketone body metabolism and cardiometabolic implications for cognitive health.酮体代谢及其对认知健康的心脏代谢影响。
NPJ Metab Health Dis. 2024;2. doi: 10.1038/s44324-024-00029-y. Epub 2024 Oct 11.
3
An alternative route for β-hydroxybutyrate metabolism supports fatty acid synthesis in cancer cells.β-羟基丁酸代谢的另一条途径支持癌细胞中的脂肪酸合成。
bioRxiv. 2024 Nov 3:2024.10.31.621317. doi: 10.1101/2024.10.31.621317.
4
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.酮体在燃料代谢、信号传导和治疗中的多维作用
Cell Metab. 2017 Feb 7;25(2):262-284. doi: 10.1016/j.cmet.2016.12.022.
5
Ketone body metabolism and cardiovascular disease.酮体代谢与心血管疾病。
Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1060-76. doi: 10.1152/ajpheart.00646.2012. Epub 2013 Feb 8.
6
The activities and intracellular distributions of enzymes of carbohydrate, lipid and ketone-body metabolism in lactating mammary glands from ruminants and non-ruminants.反刍动物和非反刍动物泌乳乳腺中碳水化合物、脂质和酮体代谢酶的活性及细胞内分布。
Biochem J. 1981 Jun 15;196(3):747-56. doi: 10.1042/bj1960747.
7
NADP-dependent dehydrogenases in rat liver parenchyma. III. The description of a liponeogenic area on the basis of histochemically demonstrated enzyme activities and the neutral fat content during fasting and refeeding.大鼠肝实质中的NADP依赖性脱氢酶。III. 根据组织化学显示的酶活性及禁食和再喂食期间的中性脂肪含量对一个脂肪生成区域的描述。
Histochemistry. 1981;72(4):579-615. doi: 10.1007/BF00493277.
8
Regulation of fatty acid metabolism and gluconeogenesis by growth hormone and insulin in sheep hepatocyte cultures. Effects of lactation and pregnancy.生长激素和胰岛素对绵羊肝细胞培养物中脂肪酸代谢和糖异生的调节。泌乳和妊娠的影响。
Biochem J. 1991 Feb 15;274 ( Pt 1)(Pt 1):21-6. doi: 10.1042/bj2740021.
本文引用的文献
1
Recycling of intravenously injected palmitic acid-1-C14 as esterified fatty acid in the plasma of rats and turnover rate of plasma triglycerides.静脉注射的棕榈酸 -1-C14 在大鼠血浆中作为酯化脂肪酸的再循环以及血浆甘油三酯的周转率。
Acta Physiol Scand. 1959 Nov 15;47:218-32. doi: 10.1111/j.1748-1716.1960.tb00072.x.
2
THE METABOLISM OF FATTY ACIDS IN THE RAT. I. PALMITIC ACID.大鼠体内脂肪酸的代谢。I. 棕榈酸
Acta Physiol Scand. 1964 Nov;62:224-39. doi: 10.1111/j.1748-1716.1964.tb03970.x.
3
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
4
Cardiovascular changes during lactation in the rat.大鼠哺乳期的心血管变化。
J Endocrinol. 1969 Jun;44(2):247-54. doi: 10.1677/joe.0.0440247.
5
Turnover rates of ketone bodies in normal, starved and alloxan-diabetic rats.正常、饥饿和四氧嘧啶糖尿病大鼠体内酮体的周转率
Biochem J. 1968 Dec;110(4):655-61. doi: 10.1042/bj1100655.
6
Biosynthesis of lipids from (2-14C)acetate and D(-)-beta-hydroxy(1,3-14C)butyrate by mammary cells from bovine and rat.牛和大鼠乳腺细胞利用（2-¹⁴C）乙酸盐和D（-）-β-羟基（1,3-¹⁴C）丁酸盐合成脂质。
Biochim Biophys Acta. 1970 Jun 9;210(1):28-38. doi: 10.1016/0005-2760(70)90058-5.
7
A role of acetoacetyl-CoA synthetase in acetoacetate utilization by rat liver cell fractions.乙酰乙酰辅酶A合成酶在大鼠肝细胞组分利用乙酰乙酸中的作用。
Biochem Biophys Res Commun. 1971 Aug 20;44(4):1001-7. doi: 10.1016/0006-291x(71)90811-4.
8
Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.乙酰乙酸与脑脂肪生成：大鼠脑可溶性部分中乙酰乙酰辅酶A合成酶的发育模式
Biochem J. 1973 Mar;132(3):653-6. doi: 10.1042/bj1320653.
9
Lactating mammary gland of the rat: a potential major site of ketone-body utilization.大鼠的泌乳乳腺：酮体利用的一个潜在主要部位。
Biochem J. 1972 Jun;128(2):459-60. doi: 10.1042/bj1280459.
10
Acetoacetyl-CoA synthetase; a lipogenic enzyme in rat tissues.乙酰乙酰辅酶A合成酶；大鼠组织中的一种生脂酶。
FEBS Lett. 1975 Dec 1;60(1):7-10. doi: 10.1016/0014-5793(75)80406-6.
Zotero 插件