视黄酸中的非编码RNA作为分化和疾病驱动因素

García-Padilla Carlos, Lozano-Velasco Estefanía, López-Sánchez Carmen, Garcia-Martínez Virginio, Aranega Amelia, Franco Diego

Department of Experimental Biology, University of Jaen, 23071 Jaen, Spain.

Department of Human Anatomy and Embryology, University of Extremadura, 06006 Badajoz, Spain.

Noncoding RNA. 2021 Feb 17;7(1):13. doi: 10.3390/ncrna7010013.

All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease.

全反式维甲酸（RA）是维生素A最具活性的代谢产物。多项研究已描述了RA信号在不同生物学过程（如细胞生长与分化、胚胎发育和器官形成）中起关键作用。由于RA信号高度依赖剂量，因此需要一种精细调节的调控机制。因此，RA信号失调在发育和疾病中都有重大影响，在许多情况下与致癌过程相关。在本综述中，我们聚焦于非编码RNA转录后调控机制，尤其是微小RNA和长链非编码RNA的调控机制，在分化和疾病过程中对RA信号通路的影响。