Hussin Mohamed Saiful Firdaus, Mohd Serah Aludin, Azlan Khairul Azri, Abdullah Hasan Zuhudi, Idris Maizlinda Izwana, Ghazali Ihwan, Mohd Shariff Amir Husni, Huda Nurul, Zakaria Azrul Abidin
Faculty of Mechanical and Manufacturing Engineering Technology, Universiti Teknikal Malaysia Melaka, Durian Tunggal, Melaka 76100, Malaysia.
Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn Malaysia, Batu Pahat, Johor 86400, Malaysia.
Polymers (Basel). 2021 Feb 22;13(4):647. doi: 10.3390/polym13040647.
Collecting information from previous investigations and expressing it in a scientometrics study can be a priceless guide to getting a complete overview of a specific research area. The aim of this study is to explore the interrelated connection between alginate, gelatine, and hydroxyapatite within the scope of bone tissue and scaffold. A review of traditional literature with data mining procedures using bibliometric analyses was considered to identify the evolution of the selected research area between 2009 and 2019. Bibliometric methods and knowledge visualization technologies were implemented to investigate diverse publications based on the following indicators: year of publication, document type, language, country, institution, author, journal, keyword, and number of citations. An analysis using a bibliometric study found that 7446 papers were located with the keywords "bone tissue" and "scaffold", and 1767 (alginate), 185 (gelatine), 5658 (hydroxyapatite) papers with those specific sub keywords. The number of publications that relate to "tissue engineering" and bone more than doubled between 2009 (1352) and 2019 (2839). China, the United States and India are the most productive countries, while Sichuan University and the Chinese Academy of Science from China are the most important institutions related to bone tissue scaffold. Materials Science and Engineering C is the most productive journal, followed by the Journal of Biomedical Materials Research Part A. This paper is a starting point, providing the first bibliometric analysis study of bone tissue and scaffold considering alginate, gelatine and hydroxyapatite. A bibliometric analysis would greatly assist in giving a scientific insight to support desired future research work, not only associated with bone tissue engineering applications. It is expected that the analysis of alginate, gelatine and hydroxyapatite in terms of 3D bioprinting, clinical outcomes, scaffold architecture, and the regenerative medicine approach will enhance the research into bone tissue engineering in the near future. Continued studies into these research fields are highly recommended.
从以往的研究中收集信息并将其体现在科学计量学研究中，对于全面了解特定研究领域而言可能是一份无比珍贵的指南。本研究的目的是在骨组织和支架范围内探索藻酸盐、明胶和羟基磷灰石之间的相互联系。本研究采用文献计量分析的数据挖掘程序对传统文献进行综述，以确定2009年至2019年所选研究领域的发展历程。运用文献计量方法和知识可视化技术，基于以下指标对各类出版物进行调查：出版年份、文献类型、语言、国家、机构、作者、期刊、关键词以及被引次数。一项文献计量研究分析发现，以“骨组织”和“支架”为关键词检索到7446篇论文，其中1767篇（藻酸盐）、185篇（明胶）、5658篇（羟基磷灰石）论文带有这些特定子关键词。与“组织工程”和骨相关的出版物数量在2009年（1352篇）至2019年（2839篇）期间增加了一倍多。中国、美国和印度是产出最多的国家，而中国的四川大学和中国科学院是与骨组织支架相关的最重要机构。《材料科学与工程C》是产出最多的期刊，其次是《生物医学材料研究杂志A辑》。本文是一个起点，提供了第一项考虑藻酸盐、明胶和羟基磷灰石的骨组织和支架的文献计量分析研究。文献计量分析将极大地有助于提供科学见解，以支持未来所需的研究工作，不仅涉及骨组织工程应用。预计在3D生物打印、临床结果、支架结构和再生医学方法方面对藻酸盐、明胶和羟基磷灰石的分析将在不久的将来加强对骨组织工程的研究。强烈建议继续对这些研究领域进行研究。
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