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用于骨组织工程的含壳聚糖-明胶/铈锌掺杂羟基磷灰石的冷冻凝胶生物复合材料。

Cryogel biocomposite containing chitosan-gelatin/cerium-zinc doped hydroxyapatite for bone tissue engineering.

作者信息

Wu Shiqing, Ma Shengzhong, Zhang Cheng, Cao Guangqing, Wu Dongjin, Gao Chunzheng, Lakshmanan Sivalingam

机构信息

Department of Spinal Surgery, The Second Hospital of Shandong University, No.247 Beiyuan Road, Tianqiao District, Jinan City, Shandong Province 250033, China.

Department of Chemistry, BIHER, Bharath University, Chennai 600 073, India.

出版信息

Saudi J Biol Sci. 2020 Oct;27(10):2638-2644. doi: 10.1016/j.sjbs.2020.05.045. Epub 2020 Jun 1.

DOI:10.1016/j.sjbs.2020.05.045
PMID:32994722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7499119/
Abstract

The present examination includes manufacture and portrayal of cryogel bio-composite implants containing chitosan-gelatin (CS-GT), cerium-zinc doped hydroxyapatite (CS-GT/Ce-Zn-HA) by cryogelation technique. The prepared cryogel biocomposites (CS-GT/HA and CS-GT/Ce-Zn-HA) were described by scanning electron microscope (SEM) and X-Ray diffraction (XRD) contemplates. The expansion of Ce-Zn in the CS-GT implants essentially expanded growing, diminished swelling, expanded protein sorption, and expanded bactericidal movement. The CS-GT/Ce-Zn-HA biocomposite had non-toxic towards rodent osteoblast cells. So the created CS-GT/Ce-Zn-HA biocomposite has favorable and potential applications over the CS-GT/HA platforms for bone tissue engineering.

摘要

本次研究包括通过冷冻凝胶化技术制备和描述含有壳聚糖-明胶（CS-GT）、铈锌掺杂羟基磷灰石（CS-GT/Ce-Zn-HA）的冷冻凝胶生物复合植入物。通过扫描电子显微镜（SEM）和X射线衍射（XRD）分析对制备的冷冻凝胶生物复合材料（CS-GT/HA和CS-GT/Ce-Zn-HA）进行了描述。CS-GT植入物中Ce-Zn的加入显著促进了生长、减少了肿胀、增加了蛋白质吸附并增强了杀菌活性。CS-GT/Ce-Zn-HA生物复合材料对啮齿动物成骨细胞无毒。因此，所制备的CS-GT/Ce-Zn-HA生物复合材料在骨组织工程方面比CS-GT/HA平台具有更有利和潜在的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/0d2079676dce/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/36f927c9806d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/35d9c369d42f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/d21f346c7904/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/163e9279abb7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/6477c8052e8f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/1760871f15c7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/0d2079676dce/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/36f927c9806d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/35d9c369d42f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/d21f346c7904/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/163e9279abb7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/6477c8052e8f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/1760871f15c7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f14/7499119/0d2079676dce/gr7.jpg

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