Sena-Dos-Santos Camille, Braga-da-Silva Cíntia, Marques Diego, Azevedo Dos Santos Pinheiro Jhully, Ribeiro-Dos-Santos Ândrea, Cavalcante Giovanna C
Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66.075-110, Brazil.
Programa de Pós-Graduação em Oncologia e Ciências Médicas, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém 66.075-110, Brazil.
Cells. 2021 Feb 23;10(2):479. doi: 10.3390/cells10020479.
Malaria is a parasitic disease (caused by different species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Cell death is implicated in malaria immune responses by eliminating infected cells, but it can also provoke an intense inflammatory response and lead to severe malaria outcomes. The study of the pathophysiological role of cell death in malaria in mammalians is key to understanding the parasite-host interactions and design prophylactic and therapeutic strategies for malaria. In this work, we review malaria-triggered cell death pathways (apoptosis, autophagy, necrosis, pyroptosis, NETosis, and ferroptosis) and we discuss their potential role in the development of new approaches for human malaria therapies.
疟疾是一种由不同物种引起的寄生虫病，影响着全球数百万人。缺乏有效的疟疾药物和疫苗导致了这种疾病的发生，持续造成重大的公共卫生和社会经济问题，尤其是在低收入国家。细胞死亡通过清除被感染的细胞参与疟疾免疫反应，但它也会引发强烈的炎症反应并导致严重的疟疾后果。研究细胞死亡在哺乳动物疟疾中的病理生理作用是理解寄生虫与宿主相互作用以及设计疟疾预防和治疗策略的关键。在这项工作中，我们回顾了疟疾引发的细胞死亡途径（凋亡、自噬、坏死、焦亡、中性粒细胞胞外陷阱形成和铁死亡），并讨论了它们在开发人类疟疾治疗新方法中的潜在作用。
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