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微小 RNA 调节间充质干细胞成骨分化中的信号通路。

MicroRNAs Modulate Signaling Pathways in Osteogenic Differentiation of Mesenchymal Stem Cells.

机构信息

Department of Medical Sciences, Section of Experimental Medicine, School of Medicine, University of Ferrara, 64b Fossato di Mortara Street, 44121 Ferrara, Italy.

Center for Musculoskeletal Regeneration, Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA.

出版信息

Int J Mol Sci. 2021 Feb 27;22(5):2362. doi: 10.3390/ijms22052362.

DOI:10.3390/ijms22052362
PMID:33673409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7956574/
Abstract

Mesenchymal stem cells (MSCs) have been identified in many adult tissues and they have been closely studied in recent years, especially in view of their potential use for treating diseases and damaged tissues and organs. MSCs are capable of self-replication and differentiation into osteoblasts and are considered an important source of cells in tissue engineering for bone regeneration. Several epigenetic factors are believed to play a role in the osteogenic differentiation of MSCs, including microRNAs (miRNAs). MiRNAs are small, single-stranded, non-coding RNAs of approximately 22 nucleotides that are able to regulate cell proliferation, differentiation and apoptosis by binding the 3' untranslated region (3'-UTR) of target mRNAs, which can be subsequently degraded or translationally silenced. MiRNAs control gene expression in osteogenic differentiation by regulating two crucial signaling cascades in osteogenesis: the transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) and the Wingless/Int-1(Wnt)/β-catenin signaling pathways. This review provides an overview of the miRNAs involved in osteogenic differentiation and how these miRNAs could regulate the expression of target genes.

摘要

间充质干细胞（MSCs）已在许多成人组织中被鉴定出来，近年来它们受到了密切研究，特别是鉴于它们在治疗疾病和受损组织和器官方面的潜在用途。MSCs 能够自我复制并分化为成骨细胞，被认为是组织工程中用于骨再生的重要细胞来源。几种表观遗传因素被认为在 MSCs 的成骨分化中发挥作用，包括 microRNAs（miRNAs）。miRNAs 是大约 22 个核苷酸的小、单链、非编码 RNA，能够通过结合靶 mRNAs 的 3'非翻译区（3'-UTR）来调节细胞增殖、分化和凋亡，靶 mRNAs 随后可以被降解或翻译沉默。miRNAs 通过调节成骨作用中的两个关键信号级联来控制成骨分化中的基因表达：转化生长因子-β（TGF-β）/骨形态发生蛋白（BMP）和 Wingless/Int-1（Wnt）/β-catenin 信号通路。本综述概述了参与成骨分化的 miRNAs 以及这些 miRNAs 如何调节靶基因的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/40e21bf1344f/ijms-22-02362-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/b1a34d7e51c1/ijms-22-02362-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/c32195d73f0f/ijms-22-02362-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/d2bf6b831edd/ijms-22-02362-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/40e21bf1344f/ijms-22-02362-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/b1a34d7e51c1/ijms-22-02362-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/c32195d73f0f/ijms-22-02362-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/d2bf6b831edd/ijms-22-02362-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758a/7956574/40e21bf1344f/ijms-22-02362-g004.jpg

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[6]
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本文引用的文献

[1]
Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies.

Leukemia. 2021-7

[2]
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Front Cell Dev Biol. 2021-4-9

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Front Cell Dev Biol. 2021-1-11

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Arch Oral Biol. 2020-12

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