Department of Ophthalmology, Ankara University School of Medicine, Mamak Street Vehbi Koç Eye Hospital, Dikimevi, Ankara, Turkey.
Jpn J Ophthalmol. 2021 Jul;65(4):482-491. doi: 10.1007/s10384-021-00829-5. Epub 2021 Mar 6.
To determine the cut-off levels for choroidal thickness and choroidal vascularity index (CVI) to differentiate among pachychoroid spectrum diseases.
A retrospective comparative study METHODS: A total of 143 eyes were included. Of these 29 had uncomplicated pachychoroid (UCP), 29 had pachychoroid pigment epitheliopathy (PPE), 25 had pachychoroid neovasculopathy (PNV), 30 had central serous chorioretinopathy (CSC), and 30 had polypoidal choroidal vasculopathy (PCV). The choroidal areas were measured with ImageJ software. The CVI, the proportion of the luminal area to the total choroidal area, was assessed.
The cut-off points of central choroidal thickness were determined as 360 µm for the PPE and PCV group pair (p < 0.001), 422 µm for the PNV and CSC group pair (p = 0.026), 271 µm for the PNV and PCV group pair (p < 0.001), and 341 µm for the CSC and PCV group pair (p < 0.001). The cut-off points of CVI were 72.7 for the PPE and PCV group pair (p < 0.001), 74.7 for the PNV and CSC group pair (p = 0.005), 72.6 for the PNV and PCV group pair (p = 0.001), and 73.6 for the CSC and PCV group pair (p < 0.001).
Pachychoroid spectrum may be composed of a combination of distinct choroidal diseases with different vascular and structural characteristics.
确定脉络膜厚度和脉络膜血管指数（CVI）的截断值，以区分各种肥厚脉络膜谱疾病。
回顾性对比研究
共纳入 143 只眼。其中单纯性肥厚脉络膜（UCP）29 只眼，肥厚脉络膜色素上皮病变（PPE）29 只眼，肥厚脉络膜新生血管病变（PNV）25 只眼，中心性浆液性脉络膜视网膜病变（CSC）30 只眼，息肉状脉络膜血管病变（PCV）30 只眼。使用 ImageJ 软件测量脉络膜面积。评估脉络膜血管指数（CVI），即管腔面积与脉络膜总面积的比值。
PPE 和 PCV 组间的中央脉络膜厚度截断点为 360μm（p<0.001），PNV 和 CSC 组间的截断点为 422μm（p=0.026），PNV 和 PCV 组间的截断点为 271μm（p<0.001），CSC 和 PCV 组间的截断点为 341μm（p<0.001）。PPE 和 PCV 组间的 CVI 截断点为 72.7（p<0.001），PNV 和 CSC 组间的截断点为 74.7（p=0.005），PNV 和 PCV 组间的截断点为 72.6（p=0.001），CSC 和 PCV 组间的截断点为 73.6（p<0.001）。
肥厚脉络膜谱可能由具有不同血管和结构特征的不同脉络膜疾病组合而成。
