Research Unit of the Department of Psychiatry, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Department of Psychiatry, Psychiatry in the Region of Southern Denmark, Odense, Denmark.
J Autism Dev Disord. 2022 Jan;52(1):275-282. doi: 10.1007/s10803-021-04897-x. Epub 2021 Mar 7.
Oxidative stress has been proposed as being important in the pathophysiology of autism spectrum disorders (ASD), and heightened levels of oxidative stress has found in children with ASD. Our aim was to investigate, whether this change is temporary or persist into adulthood. We included 89 adult patients with ASD and sex and age matched controls. Plasma levels of antioxidants superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) and pro-oxidant xanthine oxidase (XO) were measured. Individuals with ASD had higher levels of SOD1, which furthermore correlated with autism severity as measured by autism quotient-score. We found no difference regarding SOD2 and XO between ASD group and controls. However, SOD1 and SOD2 were elevated in males compared to females.
氧化应激被认为在自闭症谱系障碍（ASD）的病理生理学中很重要，并且在 ASD 儿童中发现了氧化应激水平升高。我们的目的是研究这种变化是暂时的还是持续到成年。我们纳入了 89 名成年 ASD 患者和性别及年龄匹配的对照组。测量了血浆抗氧化剂超氧化物歧化酶 1（SOD1）和超氧化物歧化酶 2（SOD2）和促氧化剂黄嘌呤氧化酶（XO）的水平。患有 ASD 的个体 SOD1 水平较高，而 SOD1 水平与自闭症商数评分所衡量的自闭症严重程度进一步相关。我们在 ASD 组和对照组之间没有发现 SOD2 和 XO 的差异。然而，SOD1 和 SOD2 在男性中比女性升高。
