Venitt S, Crofton-Sleigh C, Hunt J, Speechley V, Briggs K
Lancet. 1984 Jan 14;1(8368):74-7. doi: 10.1016/s0140-6736(84)90005-9.
In a study to determine whether hospital staff who handle cytotoxic drugs show signs of drug absorption, urinary mutagenicity assays gave positive results in a high proportion of non-exposed control subjects as well as in "exposed" hospital staff and were therefore considered unsuitable for routine monitoring. Determination of urinary platinum levels with atomic-absorption spectrophotometry of untreated urine may be a useful alternative. With this method platinum levels were below the reliable limits of detection in nurses and pharmacists who handled cytotoxic drugs (including platinum-containing drugs) and in controls. The urine of cisplatin-treated patients contained an average platinum level of 7 micrograms/ml, suggesting that contact with urine from patients undergoing intensive chemotherapy may be hazardous.
在一项旨在确定处理细胞毒性药物的医院工作人员是否有药物吸收迹象的研究中，尿液诱变分析在高比例的未接触对照受试者以及“接触”的医院工作人员中均得出阳性结果，因此被认为不适用于常规监测。用原子吸收分光光度法测定未经处理尿液中的尿铂水平可能是一种有用的替代方法。采用这种方法，处理细胞毒性药物（包括含铂药物）的护士和药剂师以及对照组的铂水平均低于可靠检测限。顺铂治疗患者的尿液中铂平均水平为7微克/毫升，这表明接触接受强化化疗患者的尿液可能具有危险性。
