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潜在混杂因素及改良的弗雷明汉风险评分对预测孕妇妊娠相关疾病发生情况的研究:一项来自伊拉克巴格达的回顾性研究

Potential Confounders and a Modified Framingham Risk Score for the Prediction of Pregnancy-related Medical Conditions Occurrence among Pregnant Women: A Retrospective Study from Baghdad, Iraq.

作者信息

Al-Taie Anmar, Mohammed Nadia H, Albasry Zahraa

机构信息

Department of Pharmacy, Faculty of Pharmacy, Girne American University, Kyrenia, North Cyprus, Turkey.

Department of Clinical Laboratory Sciences, College of Pharmacy, Mustansiriya University, Baghdad, Iraq.

出版信息

J Pharm Bioallied Sci. 2020 Oct-Dec;12(4):391-399. doi: 10.4103/jpbs.JPBS_109_19. Epub 2020 Oct 8.

Abstract

BACKGROUND

The incidence of pregnancy-related medical conditions relied on a set of potential factors that could be available even before the term of pregnancy and may be associated with poor outcomes later in life. This study aimed to investigate the association between some potential predictive factors related to maternal, gestational, and clinical parameters and the incidence of pregnancy-related medical conditions in a sample of Iraqi pregnant women.

MATERIALS AND METHODS

A retrospective, observational, single-center study was carried out on 92 pregnant women during their routine visit to the obstetric clinic in a certain distinct of Baghdad province, Iraq. Demographic, gestational, and clinical records of the participants were collected and analyzed to detect the predictive factors for pregnancy-related medical conditions.

RESULTS

56.5% of the participants were at a gestational age of 25-37 weeks. 32.6% complained of pregnancy-related medical conditions, mainly gestational hypertension and diabetes mellitus. Pregnant women with pregnancy-related medical conditions were significantly correlated with a family history ( < 0.0001), previous gestational medical conditions ( < 0.001), diastolic blood pressure ( = 0.0011), different lipid panels ( = 0.0001), and maternal blood phenotype O ( = 0.0001).

CONCLUSION

Some predictive factors related to maternal, gestational, and health characteristics are correlated with the incidence of pregnancy-related medical conditions. Interventions to adjust and recognize these confounders are essentials even before pregnancy which could improve maternal health and reduce the overall risk of pregnancy-related medical conditions.

摘要

背景

与妊娠相关的医疗状况的发生率取决于一系列潜在因素,这些因素甚至在孕期之前就可能存在,并且可能与日后的不良结局相关。本研究旨在调查伊拉克孕妇样本中一些与母体、妊娠和临床参数相关的潜在预测因素与妊娠相关医疗状况发生率之间的关联。

材料与方法

对伊拉克巴格达省某一地区产科诊所的92名孕妇进行了回顾性、观察性单中心研究。收集并分析参与者的人口统计学、妊娠和临床记录,以检测妊娠相关医疗状况的预测因素。

结果

56.5%的参与者孕周为25 - 37周。32.6%的人抱怨有与妊娠相关的医疗状况,主要是妊娠高血压和糖尿病。患有与妊娠相关医疗状况的孕妇与家族病史(<0.0001)、既往妊娠相关医疗状况(<0.001)、舒张压(=0.0011)、不同血脂指标(=0.0001)以及母体血型O(=0.0001)显著相关。

结论

一些与母体、妊娠和健康特征相关的预测因素与妊娠相关医疗状况的发生率相关。甚至在怀孕前就进行调整和识别这些混杂因素的干预措施至关重要,这可以改善孕产妇健康并降低妊娠相关医疗状况的总体风险。

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