Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021.
The aim of this systematic review was to summarize and evaluate the existing evidence on the effectiveness and safety of acupuncture in relieving chronic pain-related depression (CPRD).
We searched seven online databases to identify eligible randomized controlled trials (RCTs) of acupuncture for CPRD published before September 2020. We included studies that used acupuncture as the intervention group, with or without a control group, and the control group was treated with conventional drugs. Meta-analysis was performed using RevMan 5.3 software. For outcomes, assessments were performed using the Hamilton Depression Scale (HAMD), Visual Analogue Scale (VAS), and adverse events.
Eight studies involving 636 participants were identified and included in the meta-analysis. The results showed that single acupuncture treatment and drug treatment have the same effect in improving the HAMD score (MD = -0.14, 95% CI = [-0.88, 0.59], = 0.71) and alleviating the VAS score (MD = -0.42, 95% CI = [-1.10, -0.27], = 0.23), but acupuncture treatment is safer (OR = 0.03, 95% CI = [0.01, 0.21], = 0.0003). In addition, acupuncture combined with drugs (control group) is more beneficial than single-drug treatment in improving the HAMD score (MD = -2.95, 95% CI = [-3.55, -2.36], < 0.00001) and alleviating the VAS score (MD = -1.06, 95% CI = [-1.65, -0.47], = 0.0004).
Acupuncture is an effective and safe treatment for CPRD, and acupuncture combined with drug therapy is more effective than single-drug therapy. Nevertheless, the conclusions were limited due to the low quality and a small number of included studies.
本系统评价旨在总结和评估针灸缓解慢性疼痛相关抑郁（CPRD）的有效性和安全性的现有证据。
我们检索了 7 个在线数据库，以确定 2020 年 9 月前发表的针灸治疗 CPRD 的随机对照试验（RCT）。我们纳入了使用针灸作为干预组的研究，无论是否有对照组，对照组均采用常规药物治疗。使用 RevMan 5.3 软件进行荟萃分析。对于结局，采用汉密尔顿抑郁量表（HAMD）、视觉模拟量表（VAS）和不良事件进行评估。
共纳入 8 项研究，涉及 636 名参与者。结果表明，单次针刺治疗和药物治疗在改善 HAMD 评分（MD=-0.14，95%CI=-0.88，0.59， =0.71）和缓解 VAS 评分（MD=-0.42，95%CI=-1.10，-0.27， =0.23）方面效果相同，但针刺治疗更安全（OR=0.03，95%CI=0.01，0.21， =0.0003）。此外，与单纯药物治疗相比，针刺联合药物治疗（对照组）在改善 HAMD 评分（MD=-2.95，95%CI=-3.55，-2.36， <0.00001）和缓解 VAS 评分（MD=-1.06，95%CI=-1.65，-0.47， =0.0004）方面更有益。
针灸是治疗 CPRD 的有效且安全的方法，且针灸联合药物治疗比单纯药物治疗更有效。然而，由于纳入研究的数量较少且质量较低，结论受到限制。
