牛磺酸与多巴胺在纹状体中的相互作用。

Interactions of taurine and dopamine in the striatum.

作者信息

Kontro P

机构信息

Department of Biomedical Sciences, University of Tampere, Finland.

出版信息

Adv Exp Med Biol. 1987;217:347-55. doi: 10.1007/978-1-4899-0405-8_37.

DOI:10.1007/978-1-4899-0405-8_37

PMID:3434428

Abstract

Both spontaneous and K+-stimulated taurine release from rat striatal slices were affected by dopamine and apomorphine, suggesting that dopaminergic systems are able to modulate taurine release. K+-stimulated dopamine release was potentiated by taurine, which effect may not involve dopamine autoreceptors. Taurine was able to inhibit spiperone binding to striatal membranes in a uncompetitive manner and thus interfere with the function of dopaminergic receptors.

摘要

大鼠纹状体切片中，自发性和钾离子刺激引起的牛磺酸释放均受到多巴胺和阿扑吗啡的影响，这表明多巴胺能系统能够调节牛磺酸释放。钾离子刺激引起的多巴胺释放可被牛磺酸增强，该效应可能不涉及多巴胺自身受体。牛磺酸能够以非竞争性方式抑制司哌罗宁与纹状体膜的结合，从而干扰多巴胺能受体的功能。