Department of Life Science, Hanyang University, Seoul 04763, Korea.
These authors contributed equally to this work.
Mol Cells. 2020 Feb 29;43(2):114-120. doi: 10.14348/molcells.2019.0249.
hematopoiesis is comparable to mammalian differentiation of myeloid lineages, and therefore, has been a useful model organism in illustrating the molecular and genetic basis for hematopoiesis. Multiple novel regulators and signals have been uncovered using the tools of genetics. A Runt domain protein, lozenge, is one of the first players recognized and closely studied in the hematopoietic lineage specification. Here, we explore the role of lozenge in determination of prohemocytes into a special class of hemocyte, namely the crystal cell, and discuss molecules and signals controlling the lozenge function and its implication in immunity and stress response. Given the highly conserved nature of Runt domain in both invertebrates and vertebrates, studies in will enlighten our perspectives on Runx-mediated development and pathologies.
造血作用与哺乳动物髓系分化相当，因此一直是阐明造血分子和遗传基础的有用模式生物。利用遗传学工具发现了多种新的调节因子和信号。Runt 结构域蛋白方块是造血谱系特化中最早识别和深入研究的参与者之一。在这里，我们探讨了方块在将原血细胞确定为特殊的血细胞，即晶细胞中的作用，并讨论了控制方块功能的分子和信号及其在免疫和应激反应中的意义。鉴于 Runt 结构域在无脊椎动物和脊椎动物中的高度保守性， 的研究将使我们对 Runx 介导的发育和病理有更深入的了解。
