Bautista Johanna L, Yu Shu, Tian Li
Department of Plant Sciences, University of California, Davis, California 95616, United States.
ACS Omega. 2021 Feb 18;6(8):5119-5123. doi: 10.1021/acsomega.1c00318. eCollection 2021 Mar 2.
Although synthesizes a wide range of phytochemicals, much attention has been primarily given to two phytocannabinoids, Δ-tetrahydocannabinol (THC) and cannabidiol (CBD), due to their distinctive activities in humans. These bioactivities can be further enhanced through the interaction of THC and CBD with other phytocannabinoids or non-phytocannabinoid chemicals, such as terpenes and flavonoids, a phenomenon that is termed the entourage effect. Flavonoid metabolism in and the entourage effect are currently understudied. This mini-review examines recent advances in the biosynthesis and bioactivities of cannflavins, which are prenylated (C5) and geranylated (C10) flavones that are relatively unique to . We also discuss the rapidly developing omics tools that enable discoveries in flavonoid metabolism in and manipulation of flavonoid production through biotechnology. These advances set the stage for interrogating the health benefits of flavonoids, deciphering the contribution of flavonoids to the entourage effect, and developing drugs.
尽管[植物名称]能合成多种植物化学物质，但由于Δ-四氢大麻酚（THC）和大麻二酚（CBD）在人体内具有独特活性，人们主要关注这两种植物大麻素。THC和CBD与其他植物大麻素或非植物大麻素化学物质（如萜类和黄酮类）相互作用可进一步增强这些生物活性，这一现象被称为“同伴效应”。目前，[植物名称]中黄酮类代谢和同伴效应的研究较少。本综述探讨了大麻黄酮生物合成和生物活性的最新进展，大麻黄酮是[植物名称]相对特有的戊烯基化（C5）和香叶基化（C10）黄酮。我们还讨论了快速发展的组学工具，这些工具有助于发现[植物名称]中的黄酮类代谢，并通过生物技术操纵黄酮类物质的产生。这些进展为探究[植物名称]黄酮类物质的健康益处、解读黄酮类物质对同伴效应的贡献以及开发药物奠定了基础。
