Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK.
Unilever Foods Innovation Centre, Wageningen, The Netherlands.
Physiol Rep. 2021 Mar;9(5):e14720. doi: 10.14814/phy2.14720.
The aim of this study was to examine if catechin-rich green tea abrogates the negative effects of 7-days of physical inactivity and excessive calorie-intake on insulin homeostasis and peripheral vascular function.
Using a randomized, double-blind, crossover design, twelve healthy men (29 ± 6 yrs) underwent 7-days unhealthy lifestyle (UL), including physical inactivity (-50% steps/day) and overfeeding (+50% kcal/day). This was combined with green tea consumption (UL-tea; 3 doses/day) or placebo (UL-placebo). Before and after each intervention, we examined postprandial blood glucose and insulin (3-h after a 1,202 kcal meal) and upper and lower limb vascular function (flow-mediated dilation (FMD%)) and carotid artery reactivity (CAR%).
UL-placebo increased postprandial glucose and insulin, while UL-tea decreased postprandial glucose and insulin (TimeIntervention interaction effects: both p < 0.05). UL-placebo decreased CAR% and femoral FMD%, while UL-tea prevented these effects (TimeIntervention interaction effects of p < 0.04 and p < 0.001, respectively). There was no main effect of Time or Time*Intervention interaction (both p > 0.05) for brachial FMD%.
Seven days of physical inactivity and overfeeding impair insulin homeostasis and vascular function. These effects were mitigated by a daily intake of catechin-rich green tea.
本研究旨在探讨富含儿茶素的绿茶是否能消除 7 天的身体不活动和过度热量摄入对胰岛素稳态和外周血管功能的负面影响。
采用随机、双盲、交叉设计，12 名健康男性（29±6 岁）接受 7 天的不健康生活方式（UL），包括身体不活动（每天减少 50%的步数）和过度喂养（每天增加 50%的卡路里）。这与绿茶消费（UL-茶；每天 3 剂）或安慰剂（UL-安慰剂）相结合。在每个干预前后，我们检查了餐后血糖和胰岛素（餐后 3 小时，摄入 1202 卡路里的餐食）以及上下肢血管功能（血流介导的扩张（FMD%））和颈动脉反应性（CAR%）。
UL-安慰剂增加了餐后血糖和胰岛素，而 UL-茶则降低了餐后血糖和胰岛素（时间干预交互作用效果：均 p<0.05）。UL-安慰剂降低了 CAR%和股动脉 FMD%，而 UL-茶则防止了这些影响（时间干预交互作用的 p 值分别为<0.04 和<0.001）。对于肱动脉 FMD%，没有时间或时间*干预交互作用的主要影响（两者的 p 值均>0.05）。
7 天的身体不活动和过度喂养会损害胰岛素稳态和血管功能。这些影响可以通过每天摄入富含儿茶素的绿茶来减轻。
