Organization for University Research Initiatives, Waseda University, 2-2 Wakamatsu-cho, Shinjuku, Tokyo 1628480, Japan.
Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho Shinjuku, Tokyo 1628480, Japan.
Nutrients. 2020 Feb 21;12(2):565. doi: 10.3390/nu12020565.
We examined the effects of the timing of acute and consecutive epigallocatechin gallate (EGCG) and catechin-rich green tea ingestion on postprandial glucose in mice and human adults. In mouse experiments, we compared the effects of EGCG administration early (morning) and late (evening) in the active period on postprandial glucose. In human experiments, participants were randomly assigned to the morning-placebo (MP, = 10), morning-green tea (MGT, = 10), evening-placebo (EP, = 9), and evening-green tea (EGT, = 9) groups, and consumed either catechin-rich green tea or a placebo beverage for 1 week. At baseline and after 1 week, participants consumed their designated beverages with breakfast (MP and MGT) or supper (EP and EGT). Venous blood samples were collected in the fasted state and 30, 60, 120, and 180 min after each meal. Consecutive administration of EGCG in the evening, but not in the morning, reduced postprandial glucose at 30 ( = 0.006) and 60 ( = 0.037) min in the evening trials in mice. In humans, ingestion of catechin-rich green tea in the evening decreased postprandial glucose (three-factor analysis of variance, < 0.05). Thus, catechin intake in the evening more effectively suppressed elevation of postprandial glucose.
我们研究了急性和连续儿茶素没食子酸酯（EGCG）和富含儿茶素的绿茶摄入时间对小鼠和成年人类餐后血糖的影响。在小鼠实验中，我们比较了 EGCG 在活动期早期（早晨）和晚期（晚上）给药对餐后血糖的影响。在人体实验中，参与者被随机分配到早晨安慰剂（MP，n = 10）、早晨绿茶（MGT，n = 10）、晚上安慰剂（EP，n = 9）和晚上绿茶（EGT，n = 9）组，连续一周饮用富含儿茶素的绿茶或安慰剂饮料。在基线和一周后，参与者在早餐（MP 和 MGT）或晚餐（EP 和 EGT）时饮用指定的饮料。空腹和餐后 30、60、120 和 180 分钟采集静脉血样。在晚上连续给予 EGCG，而不是在早上，可降低晚上试验中 30 分钟（ = 0.006）和 60 分钟（ = 0.037）时的餐后血糖。在人类中，晚上摄入富含儿茶素的绿茶可降低餐后血糖（三因素方差分析， < 0.05）。因此，晚上摄入儿茶素更有效地抑制餐后血糖升高。
