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一名患有2型糖尿病、乙型肝炎病毒感染和肝硬化的患者因胰岛素注射继发多灶性脂肪萎缩。

Multifocal lipoatrophy secondary to insulin injection in a patient with type 2 diabetes, hepatitis B virus infection, and liver cirrhosis.

作者信息

Wu Yuedan, Lou Xiaojia

机构信息

Department of Endocrinology, Dongyang People's Hospital, Jinhua City, Zhejiang, China.

出版信息

J Int Med Res. 2021 Mar;49(3):300060521990237. doi: 10.1177/0300060521990237.

DOI:10.1177/0300060521990237
PMID:33682487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7944535/
Abstract

Lipoatrophy secondary to insulin injection is a rare complication of insulin use. Localized lipoatrophy is recognized by a loss of subcutaneous fat caused by insulin injection. We report the case of a 69-year-old non-obese female patient with type 2 diabetes mellitus, decompensated liver cirrhosis, and hepatitis B virus (HBV) infection who developed multifocal lipoatrophy during the administration of human insulin and an insulin analog.

摘要

胰岛素注射继发的脂肪萎缩是胰岛素使用的一种罕见并发症。局部脂肪萎缩通过胰岛素注射导致的皮下脂肪缺失得以识别。我们报告了一例69岁非肥胖女性2型糖尿病患者，该患者患有失代偿期肝硬化和乙型肝炎病毒（HBV）感染，在使用人胰岛素和胰岛素类似物期间发生了多灶性脂肪萎缩。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572a/7944535/656392ff5ead/10.1177_0300060521990237-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572a/7944535/0bd99567a561/10.1177_0300060521990237-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572a/7944535/656392ff5ead/10.1177_0300060521990237-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572a/7944535/0bd99567a561/10.1177_0300060521990237-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572a/7944535/656392ff5ead/10.1177_0300060521990237-fig2.jpg

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Multifocal lipoatrophy secondary to insulin injection in a patient with type 2 diabetes, hepatitis B virus infection, and liver cirrhosis.一名患有2型糖尿病、乙型肝炎病毒感染和肝硬化的患者因胰岛素注射继发多灶性脂肪萎缩。
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本文引用的文献

1
Fatty Liver and Autoimmune Hepatitis: Two Forms of Liver Involvement in Lipodystrophies.脂肪肝与自身免疫性肝炎：脂肪营养不良中肝脏受累的两种形式。
GE Port J Gastroenterol. 2019 Aug;26(5):362-369. doi: 10.1159/000495767. Epub 2019 Jan 30.
2
An overview of lipodystrophy and the role of the complement system.脂肪营养不良概述及补体系统的作用。
Mol Immunol. 2019 Aug;112:223-232. doi: 10.1016/j.molimm.2019.05.011. Epub 2019 Jun 6.
3
Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications.脂肪组织功能障碍作为肥胖相关代谢并发症的决定因素。
Int J Mol Sci. 2019 May 13;20(9):2358. doi: 10.3390/ijms20092358.
4
Fatty liver in lipodystrophy: A review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement.脂肪性肝病与脂肪营养不良：综述及对脂联素和/或瘦素替代治疗的展望。
Metabolism. 2019 Jul;96:66-82. doi: 10.1016/j.metabol.2019.05.001. Epub 2019 May 6.
5
Lung cancer-derived extracellular vesicles induced myotube atrophy and adipocyte lipolysis via the extracellular IL-6-mediated STAT3 pathway.肺癌衍生的细胞外囊泡通过细胞外 IL-6 介导的 STAT3 通路诱导肌管萎缩和脂肪细胞脂解。
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1091-1102. doi: 10.1016/j.bbalip.2019.04.006. Epub 2019 Apr 17.
6
Energy metabolism of white adipose tissue and insulin resistance in humans.人体白色脂肪组织的能量代谢与胰岛素抵抗。
Eur J Clin Invest. 2018 Nov;48(11):e13017. doi: 10.1111/eci.13017. Epub 2018 Sep 26.
7
Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis.去神经激活的成纤维脂肪祖细胞中的 STAT3-IL-6 信号促进肌纤维萎缩和纤维化。
Nat Cell Biol. 2018 Aug;20(8):917-927. doi: 10.1038/s41556-018-0151-y. Epub 2018 Jul 26.
8
Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning.白细胞介素-6 通过促进白色脂肪组织脂解和棕色化导致癌症恶病质中的脂肪丢失。
Lipids Health Dis. 2018 Jan 16;17(1):14. doi: 10.1186/s12944-018-0657-0.
9
Inflammation and sarcopenia: A systematic review and meta-analysis.炎症与肌肉减少症：一项系统评价与荟萃分析。
Maturitas. 2017 Feb;96:10-15. doi: 10.1016/j.maturitas.2016.11.006. Epub 2016 Nov 13.
10
Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis.脂联素、肿瘤坏死因子-α及炎性细胞因子与2型糖尿病风险：一项系统评价和荟萃分析
Cytokine. 2016 Oct;86:100-109. doi: 10.1016/j.cyto.2016.06.028. Epub 2016 Aug 4.