衰老延缓：从老鼠到人。
Aging delay: of mice and men.
机构信息
Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, Pesochny, St. Petersburg, Russia.
出版信息
Acta Biomed. 2021 Jan 28;92(1):e2021073. doi: 10.23750/abm.v92i1.11273.
Abstract
The evaluation of the safety of a drug in rodents that may be used as geroprotectors is a challenge of current times. In the paper, we discuss approaches to long-term assays for selection of potent aging delay drugs for humans. Priority is given to methods combining evaluation of carcinogenic safety and life-spanning potential. The use of such methods will be time-efficient and economically feasible.
摘要
在啮齿类动物中评估可能用作抗衰老药物的药物的安全性是当前的一个挑战。本文讨论了选择用于人类的强效抗衰老药物的长期检测方法。优先考虑结合评估致癌安全性和寿命延长潜力的方法。使用这种方法将是高效省时且经济可行的。
相似文献
1
Aging delay: of mice and men.衰老延缓：从老鼠到人。
Acta Biomed. 2021 Jan 28;92(1):e2021073. doi: 10.23750/abm.v92i1.11273.
2
Life span extension and cancer risk: myths and reality.寿命延长与癌症风险：误区与真相
Exp Gerontol. 2001 Jul;36(7):1101-36. doi: 10.1016/s0531-5565(01)00114-0.
3
[Models and methods of evaluation of geroprotective activity of pharmacological drugs].[药物的老年保护活性评估模型与方法]
Adv Gerontol. 2009;22(2):237-52.
4
Rodent models for the preclinical evaluation of drugs suitable for pharmacological intervention in aging.适合衰老相关药物药理干预的临床前评价的啮齿类动物模型。
Expert Opin Drug Discov. 2012 Jan;7(1):85-95. doi: 10.1517/17460441.2012.642361. Epub 2011 Dec 1.
5
Geroprotectors: A role in the treatment of frailty.衰老防护剂：在虚弱治疗中的作用。
Mech Ageing Dev. 2019 Jun;180:11-20. doi: 10.1016/j.mad.2019.03.002. Epub 2019 Mar 15.
6
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.制定老年保护剂评估标准是迈向临床转化的关键阶段。
Aging Cell. 2016 Jun;15(3):407-15. doi: 10.1111/acel.12463. Epub 2016 Mar 11.
7
Selection for maximum longevity in mice.小鼠最长寿命的选择
Exp Gerontol. 1997 Jan-Apr;32(1-2):65-78. doi: 10.1016/s0531-5565(96)00034-4.
8
[Geroprotectors: specific action or hormesis?].[老年保护剂：特定作用还是应激效应？]
Adv Gerontol. 2008;21(4):564-9.
9
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state.寻找老年保护剂：年轻健康状态信号组水平模拟物的计算机模拟筛选和体外验证
Aging (Albany NY). 2016 Sep 24;8(9):2127-2152. doi: 10.18632/aging.101047.
10
Insulin and longevity: antidiabetic biguanides as geroprotectors.胰岛素与长寿：作为老年保护剂的抗糖尿病双胍类药物
Biogerontology. 2003;4(5):297-307. doi: 10.1023/a:1026299318315.
引用本文的文献
1
Calorie restriction mimetics against aging and inflammation.抗老化和抗炎的卡路里限制模拟物。
Biogerontology. 2025 Jun 24;26(4):126. doi: 10.1007/s10522-025-10269-0.
本文引用的文献
1
It is necessary to establish an International Agency for Research on Aging.有必要设立一个国际老龄问题研究机构。
Aging (Albany NY). 2018 May 12;10(5):863-867. doi: 10.18632/aging.101451.
2
2nd interventions in aging conference.第二届衰老干预会议
Aging (Albany NY). 2017 Apr;9(4):1090-1095. doi: 10.18632/aging.101221.
3
NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model.美国国立衰老研究所干预测试项目：在基因异质性小鼠模型中研究假定的衰老干预剂。
EBioMedicine. 2017 Jul;21:3-4. doi: 10.1016/j.ebiom.2016.11.038. Epub 2016 Dec 2.
4
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state.寻找老年保护剂：年轻健康状态信号组水平模拟物的计算机模拟筛选和体外验证
Aging (Albany NY). 2016 Sep 24;8(9):2127-2152. doi: 10.18632/aging.101047.
5
Anti-aging pharmacology: Promises and pitfalls.抗衰老药理学：前景与陷阱。
Ageing Res Rev. 2016 Nov;31:9-35. doi: 10.1016/j.arr.2016.08.004. Epub 2016 Aug 11.
6
Metformin for cancer and aging prevention: is it a time to make the long story short?二甲双胍用于癌症预防和延缓衰老：是时候言简意赅了吗？
Oncotarget. 2015 Nov 24;6(37):39398-407. doi: 10.18632/oncotarget.6347.
7
Interventions to Slow Aging in Humans: Are We Ready?延缓人类衰老的干预措施：我们准备好了吗？
Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22.
8
Aging interventions get human.衰老干预走向人性化。
Oncotarget. 2015 Jan 20;6(2):590-1. doi: 10.18632/oncotarget.3173.
9
Koschei the immortal and anti-aging drugs.不朽者科谢伊与抗衰老药物。
Cell Death Dis. 2014 Dec 4;5(12):e1552. doi: 10.1038/cddis.2014.520.
10
Methods of testing pharmacological drugs effects on aging and life span in mice.测试药物对小鼠衰老和寿命影响的方法。
Methods Mol Biol. 2013;1048:145-60. doi: 10.1007/978-1-62703-556-9_12.
Zotero 插件