A组链球菌细胞壁的持续存在与兔真皮结缔组织的慢性炎症相关。
Persistence of group a streptococcal cell walls related to chronic inflammation of rabbit dermal connective tissue.
作者信息
Ohanian S H, Schwab J H
出版信息
J Exp Med. 1967 Jun 1;125(6):1137-48. doi: 10.1084/jem.125.6.1137.
Abstract
Antibodies specific for the mucopeptide and group-specific C polysaccharide antigens of Group A streptococcal cell walls were prepared by acid dissociation of immune precipitates, and labeled with either fluorescein or (125)I. Employing both fluorescent and radioautographic procedures the persistence of the antigens was followed in skin sites injected with cell wall fragments. Both antigens persisted within macrophages for at least 54 days in those animals which developed no chronic tissue response. In animals which did develop chronic nodular lesions the concentration of antigen decreased as the inflammatory process subsided. Lesion activity was thus associated with the presence of cell wall material. The fate of these antigens was also determined following the intradermal injection of intact Group A streptococcal cells. Cell wall antigens persisted in the tissue site considerably longer than morphologically identifiable streptococci, indicating that cell wall fragments are released during dismantling of streptococci in phagocytic cells.
摘要
通过免疫沉淀物的酸解离制备了针对A组链球菌细胞壁的粘肽和群特异性C多糖抗原的特异性抗体，并用荧光素或（125）I进行标记。采用荧光和放射自显影程序，追踪注射细胞壁片段的皮肤部位抗原的持久性。在没有发生慢性组织反应的动物中，两种抗原在巨噬细胞内至少持续存在54天。在确实发生慢性结节性病变的动物中，随着炎症过程消退，抗原浓度降低。因此，病变活动与细胞壁物质的存在有关。在皮内注射完整的A组链球菌细胞后，也确定了这些抗原的命运。细胞壁抗原在组织部位持续存在的时间比形态上可识别的链球菌长得多，这表明细胞壁片段是在吞噬细胞中链球菌解体过程中释放出来的。
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Persistence of group a streptococcal cell walls related to chronic inflammation of rabbit dermal connective tissue.A组链球菌细胞壁的持续存在与兔真皮结缔组织的慢性炎症相关。
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