Department of Biotechnology, Maharaja Sriramchandra Bhanjadeo University, Takatpur, Baripada, Odisha, 75003, India.
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, 110067, India.
Hum Cell. 2021 May;34(3):734-744. doi: 10.1007/s13577-021-00513-3. Epub 2021 Mar 8.
In malaria-endemic countries, the burden of hypertension is on the rise. Although malaria and hypertension seem to have no direct link, several studies in recent years support their possible link. Three bioactive molecules such as angiotensin II (Ang II), bradykinin (BK) and sphingosine 1-phosphate (S1P) are crucial in regulating blood pressure. While the increased level of Ang II and S1P are responsible for inducing hypertension, BK is arthero-protective and anti-hypertensive. Therefore, in the present review, based on available literatures we highlight the present knowledge on the production and bioavailability of these molecules, the mechanism of their regulation of hypertension, and patho-physiological role in malaria. Further, a possible link between malaria and hypertension is hypothesized through various arguments based on experimental evidence. Understanding of their mechanisms of blood pressure regulation during malaria infection may open up avenues for drug therapeutics and management of malaria in co-morbidity with hypertension.
在疟疾流行的国家，高血压的负担正在增加。尽管疟疾和高血压似乎没有直接联系，但近年来的几项研究支持它们可能存在联系。三种生物活性分子，如血管紧张素 II（Ang II）、缓激肽（BK）和 1-磷酸鞘氨醇（S1P），在调节血压方面起着至关重要的作用。虽然 Ang II 和 S1P 的水平升高会导致高血压，而 BK 则具有抗动脉粥样硬化和降压作用。因此，在本综述中，我们根据现有文献，重点介绍了这些分子的产生和生物利用度、它们调节高血压的机制以及在疟疾中的病理生理作用的现有知识。此外，还通过基于实验证据的各种论点假设了疟疾和高血压之间的可能联系。了解它们在疟疾感染期间调节血压的机制可能为药物治疗和高血压合并疟疾的管理开辟新途径。
