Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK.
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, S10 2TN, UK.
Cell Mol Life Sci. 2021 May;78(9):4377-4398. doi: 10.1007/s00018-021-03790-1. Epub 2021 Mar 10.
The cerebral vasculature plays a central role in human health and disease and possesses several unique anatomic, functional and molecular characteristics. Despite their importance, the mechanisms that determine cerebrovascular development are less well studied than other vascular territories. This is in part due to limitations of existing models and techniques for visualisation and manipulation of the cerebral vasculature. In this review we summarise the experimental approaches used to study the cerebral vessels and the mechanisms that contribute to their development.
脑血管在人类健康和疾病中起着核心作用，具有多种独特的解剖、功能和分子特征。尽管它们很重要，但决定脑血管发育的机制研究还不如其他血管领域那么深入。这在一定程度上是由于现有的用于可视化和操作脑血管的模型和技术存在局限性。在这篇综述中，我们总结了用于研究脑血管的实验方法以及促成其发育的机制。
