Department of Clinical Nutrition, Food Security and Nutrition Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Gastroenterlogy and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Arch Physiol Biochem. 2023 Dec;129(4):975-983. doi: 10.1080/13813455.2021.1890128. Epub 2021 Mar 9.
The aim of the study was to compare the effects of a lacto-ovo-vegetarian diet (LOV-D) a standard weight-loss diet (SWL-D) on obese/overweight adults with NAFLD. Present randomised clinical trial recruited 75 overweight/obese adults with NAFLD, who were randomly assigned into LOV-D and SWL-D groups for 3 months. The LOV-D was designed based on eliminating meat, poultry, and fish; while including dairy products and eggs. The SWL-D was planned according to the standard food pyramid, which was free in all sources of food. Adherence to LOV-D significantly outperformed SWL-D in reducing levels of alanine aminotransferase (ALT), body weight, waist circumference, BMI, fasting blood sugar, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triacylglycerol (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), and systolic blood pressure (SBP). Furthermore, ultrasonography revealed a higher alleviation in NAFLD grade among LOV-D, compared with SWL-D. This study suggests that adherence to LOV-D for 3 months has beneficial effects on NAFLD improvement, anthropometric measures, glycaemic-related markers, and lipid profiles.
本研究旨在比较乳蛋素食饮食（LOV-D）和标准减肥饮食（SWL-D）对非酒精性脂肪性肝病（NAFLD）肥胖/超重成年人的影响。本随机临床试验招募了 75 名超重/肥胖的 NAFLD 患者，将其随机分为 LOV-D 组和 SWL-D 组，分别进行 3 个月的干预。LOV-D 的设计基于消除肉类、家禽和鱼类，同时包括乳制品和蛋类。SWL-D 则根据标准食物金字塔进行规划，该饮食不受食物来源的限制。与 SWL-D 相比，LOV-D 在降低丙氨酸氨基转移酶（ALT）、体重、腰围、BMI、空腹血糖、胰岛素、胰岛素抵抗评估的稳态模型（HOMA-IR）、三酰甘油（TG）、胆固醇、低密度脂蛋白胆固醇（LDL-C）和收缩压（SBP）水平方面具有显著优势。此外，超声检查显示 LOV-D 组的 NAFLD 严重程度改善更为明显。本研究表明，坚持 LOV-D 饮食 3 个月对改善 NAFLD、人体测量指标、血糖相关标志物和血脂谱具有有益作用。
