Department of Human Anatomy and Cell Science, University of Manitoba, 130-745 Bannatyne Ave., Winnipeg, MB, R3E 0J9, Canada.
Kleysen Institute for Advanced Medicine, Health Science Centre, Winnipeg, MB, Canada.
Mol Med. 2021 Mar 10;27(1):24. doi: 10.1186/s10020-021-00284-5.
Parkinson's disease (PD) is a relatively well characterised neurological disorder that primarily affects motor and cognitive functions. This paper reviews on how transcranial direct current stimulation (tDCS) can be used to modulate brain networks associated with cognitive deficits in PD. We first provide an overview of brain network abnormalities in PD, by introducing the brain network modulation approaches such as pharmacological interventions and brain stimulation techniques. We then present the potential underlying mechanisms of tDCS technique, and specifically highlight how tDCS can be applied to modulate brain network abnormality associated with cognitive dysfunction among PD patients. More importantly, we address the limitations of existing studies and suggest possible future directions, with the aim of helping researchers to further develop the use of tDCS technique in clinical settings.
帕金森病（PD）是一种相对特征明显的神经退行性疾病，主要影响运动和认知功能。本文综述了经颅直流电刺激（tDCS）如何用于调节与 PD 认知缺陷相关的大脑网络。我们首先通过介绍脑网络调制方法（如药物干预和脑刺激技术），概述 PD 中的脑网络异常。然后，我们提出 tDCS 技术的潜在潜在机制，并特别强调 tDCS 如何应用于调节与 PD 患者认知功能障碍相关的脑网络异常。更重要的是，我们解决了现有研究的局限性，并提出了可能的未来方向，旨在帮助研究人员进一步将 tDCS 技术应用于临床环境。
