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调节帕金森病认知缺陷相关的大脑网络。

Modulating brain networks associated with cognitive deficits in Parkinson's disease.

机构信息

Department of Human Anatomy and Cell Science, University of Manitoba, 130-745 Bannatyne Ave., Winnipeg, MB, R3E 0J9, Canada.

Kleysen Institute for Advanced Medicine, Health Science Centre, Winnipeg, MB, Canada.

出版信息

Mol Med. 2021 Mar 10;27(1):24. doi: 10.1186/s10020-021-00284-5.


DOI:10.1186/s10020-021-00284-5
PMID:33691622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7945662/
Abstract

Parkinson's disease (PD) is a relatively well characterised neurological disorder that primarily affects motor and cognitive functions. This paper reviews on how transcranial direct current stimulation (tDCS) can be used to modulate brain networks associated with cognitive deficits in PD. We first provide an overview of brain network abnormalities in PD, by introducing the brain network modulation approaches such as pharmacological interventions and brain stimulation techniques. We then present the potential underlying mechanisms of tDCS technique, and specifically highlight how tDCS can be applied to modulate brain network abnormality associated with cognitive dysfunction among PD patients. More importantly, we address the limitations of existing studies and suggest possible future directions, with the aim of helping researchers to further develop the use of tDCS technique in clinical settings.

摘要

帕金森病(PD)是一种相对特征明显的神经退行性疾病,主要影响运动和认知功能。本文综述了经颅直流电刺激(tDCS)如何用于调节与 PD 认知缺陷相关的大脑网络。我们首先通过介绍脑网络调制方法(如药物干预和脑刺激技术),概述 PD 中的脑网络异常。然后,我们提出 tDCS 技术的潜在潜在机制,并特别强调 tDCS 如何应用于调节与 PD 患者认知功能障碍相关的脑网络异常。更重要的是,我们解决了现有研究的局限性,并提出了可能的未来方向,旨在帮助研究人员进一步将 tDCS 技术应用于临床环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d345/7945662/dbda38545329/10020_2021_284_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d345/7945662/dbda38545329/10020_2021_284_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d345/7945662/dbda38545329/10020_2021_284_Fig1_HTML.jpg

相似文献

[1]
Modulating brain networks associated with cognitive deficits in Parkinson's disease.

Mol Med. 2021-3-10

[2]
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Int Rev Neurobiol. 2017

[3]
Nonmotor Symptoms and Natural History of Parkinson's Disease: Evidence From Cognitive Dysfunction and Role of Noninvasive Interventions.

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[4]
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[5]
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[6]
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[7]
Registered report: Does transcranial direct current stimulation of the primary motor cortex improve implicit motor sequence learning in Parkinson's disease?

J Neurosci Res. 2021-10

[8]
Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease.

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[9]
Repeated High-Definition Transcranial Direct Current Stimulation Modulated Temporal Variability of Brain Regions in Core Neurocognitive Networks Over the Left Dorsolateral Prefrontal Cortex in Mild Cognitive Impairment Patients.

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[10]
Transcranial direct current stimulation combined with cognitive training for the treatment of Parkinson Disease: A randomized, placebo-controlled study.

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引用本文的文献

[1]
Predicting the Conversion from Mild Cognitive Impairment to Alzheimer's Disease Using Graph Frequency Bands and Functional Connectivity-Based Features.

Res Sq. 2024-6-21

[2]
The Effects of Transcranial Direct Current Stimulation (tDCS) in HIV Patients-A Review.

J Clin Med. 2024-6-3

[3]
Predicting the occurrence of mild cognitive impairment in Parkinson's disease using structural MRI data.

Front Neurosci. 2024-4-18

[4]
Effect of Transcranial Direct Current Stimulation (tDCS) on Depression in Parkinson's Disease-A Narrative Review.

J Clin Med. 2024-1-25

[5]
Resting state EEG as biomarker of cognitive training and physical activity's joint effect in Parkinson's patients with mild cognitive impairment.

Neurol Res Pract. 2023-9-14

[6]
Classification of early-MCI patients from healthy controls using evolutionary optimization of graph measures of resting-state fMRI, for the Alzheimer's disease neuroimaging initiative.

PLoS One. 2022

[7]
Transcranial Direct Current Stimulation Enhances Cognitive Function in Patients with Mild Cognitive Impairment and Early/Mid Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Brain Sci. 2022-4-27

[8]
Efficacy and Safety of Transcranial Direct Current Stimulation on Post-Stroke Dysphagia: A Systematic Review and Meta-Analysis.

J Clin Med. 2022-4-20

[9]
Efficacy of Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex in Patients With Minimally Conscious State.

Front Neurol. 2022-2-18

[10]
Identifying Mild Cognitive Impairment in Parkinson's Disease With Electroencephalogram Functional Connectivity.

Front Aging Neurosci. 2021-7-1

本文引用的文献

[1]
Imaging Cerebral Glucose Metabolism during Dual-Task Walking in Patients with Parkinson's disease.

J Neuroimaging. 2021-3

[2]
Transcranial direct current stimulation (tDCS) over the auditory cortex modulates GABA and glutamate: a 7 T MR-spectroscopy study.

Sci Rep. 2020-11-18

[3]
Diffusion Tensor Imaging in Parkinson's Disease and Parkinsonian Syndrome: A Systematic Review.

Front Neurol. 2020-9-25

[4]
Non-invasive Brain Stimulation in Alzheimer's Disease and Mild Cognitive Impairment-A State-of-the-Art Review on Methodological Characteristics and Stimulation Parameters.

Front Hum Neurosci. 2020-5-25

[5]
Transcranial Direct Current Stimulation in ADHD: A Systematic Review of Efficacy, Safety, and Protocol-induced Electrical Field Modeling Results.

Neurosci Bull. 2020-10

[6]
Methodology for tDCS integration with fMRI.

Hum Brain Mapp. 2020-5

[7]
Grey matter abnormalities in Parkinson's disease: a voxel-wise meta-analysis.

Eur J Neurol. 2020-4

[8]
tDCS-Enhanced Consolidation of Writing Skills and Its Associations With Cortical Excitability in Parkinson Disease: A Pilot Study.

Neurorehabil Neural Repair. 2019-11-18

[9]
Dopamine and the motivation of cognitive control.

Handb Clin Neurol. 2019

[10]
Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease.

CNS Neurosci Ther. 2019-8-19

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