Trenado Carlos, Trauberg Paula, Elben Saskia, Dimenshteyn Karina, Folkerts Ann-Kristin, Witt Karsten, Weiss Daniel, Liepelt-Scarfone Inga, Kalbe Elke, Wojtecki Lars
Center for Movement Disorders and Neuromodulation, Departmemt of Neurology, University Clinic Duesseldorf, Duesseldorf, Germany.
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Neurol Res Pract. 2023 Sep 14;5(1):46. doi: 10.1186/s42466-023-00273-5.
Cognitive decline is a major factor for the deterioration of the quality of life in patients suffering from Parkinson's disease (PD). Recently, it was reported that cognitive training (CT) in PD patients with mild cognitive impairment (PD-MCI) led to an increase of physical activity (PA) accompanied by improved executive function (EF). Moreover, PA has been shown to alter positively brain function and cognitive abilities in PD. Both observations suggest an interaction between CT and PA.
A previous multicenter (MC) study was slightly significant when considering independent effects of interventions (CT and PA) on EF. Here, we use MC constituent single center data that showed no effect of interventions on EF. Thus, this exploratory study considers pooling data from both interventions to gain insight into a recently reported interaction between CT and PA and provide a proof of principle for the usefulness of resting state EEG as a neurophysiological biomarker of joint intervention's effect on EF and attention in PD-MCI.
Pre- and post-intervention resting state EEG and neuropsychological scores (EF and attention) were obtained from 19 PD-MCI patients (10 (CT) and 9 (PA)). We focused our EEG analysis on frontal cortical areas due to their relevance on cognitive function.
We found a significant joint effect of interventions on EF and a trend on attention, as well as trends for the negative correlation between attention and theta power (pre), the positive correlation between EF and alpha power (post) and a significant negative relationship between attention and theta power over time (post-pre).
Our results support the role of theta and alpha power at frontal areas as a biomarker for the therapeutic joint effect of interventions.
认知功能衰退是帕金森病（PD）患者生活质量恶化的主要因素。最近，有报道称，对轻度认知障碍的帕金森病患者（PD-MCI）进行认知训练（CT）可使身体活动（PA）增加，同时执行功能（EF）得到改善。此外，PA已被证明可对PD患者的脑功能和认知能力产生积极影响。这两项观察结果表明CT与PA之间存在相互作用。
之前的一项多中心（MC）研究在考虑干预措施（CT和PA）对EF的独立影响时，结果略显显著。在此，我们使用MC各组成单中心的数据，这些数据显示干预措施对EF没有影响。因此，这项探索性研究考虑将两种干预措施的数据合并，以深入了解最近报道的CT与PA之间的相互作用，并为静息态脑电图作为联合干预对PD-MCI患者EF和注意力影响的神经生理学生物标志物的有效性提供原理证明。
从19名PD-MCI患者（10名接受CT，9名接受PA）中获取干预前后的静息态脑电图和神经心理学评分（EF和注意力）。由于额叶皮质区域与认知功能相关，我们将脑电图分析重点放在该区域。
我们发现干预措施对EF有显著的联合效应，对注意力有一定趋势，以及注意力与θ波功率（干预前）之间呈负相关、EF与α波功率（干预后）之间呈正相关以及注意力与θ波功率随时间（干预后-干预前）呈显著负相关的趋势。
我们的结果支持额叶区域的θ波和α波功率作为干预措施治疗联合效应生物标志物的作用。
