• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

游离DNA：癌症中的希望与潜在应用

Cell-Free DNA: Hope and Potential Application in Cancer.

作者信息

Yan Yan-Yan, Guo Qiao-Ru, Wang Feng-Hua, Adhikari Rameshwar, Zhu Zhuang-Yan, Zhang Hai-Yan, Zhou Wen-Min, Yu Hua, Li Jing-Quan, Zhang Jian-Ye

机构信息

School of Medicine, Shanxi Datong University, Datong, China.

Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

出版信息

Front Cell Dev Biol. 2021 Feb 22;9:639233. doi: 10.3389/fcell.2021.639233. eCollection 2021.

DOI:10.3389/fcell.2021.639233
PMID:33693004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7938321/
Abstract

Cell-free DNA (cfDNA) is easily accessible in peripheral blood and can be used as biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA in various areas of cancer management are attracting attention. In this review article, we discuss the potential relevance of using cfDNA analysis in clinical oncology, particularly in cancer screening, early diagnosis, therapeutic evaluation, monitoring disease progression; and determining disease prognosis.

摘要

游离DNA（cfDNA）在外周血中易于获取，可作为癌症诊断、预后评估和治疗的生物标志物。cfDNA在癌症管理各个领域的应用正引起关注。在这篇综述文章中，我们讨论了在临床肿瘤学中使用cfDNA分析的潜在相关性，特别是在癌症筛查、早期诊断、治疗评估、监测疾病进展以及确定疾病预后方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edff/7938321/12b543abb70f/fcell-09-639233-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edff/7938321/12b543abb70f/fcell-09-639233-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edff/7938321/12b543abb70f/fcell-09-639233-g0001.jpg

相似文献

1
Cell-Free DNA: Hope and Potential Application in Cancer.游离DNA：癌症中的希望与潜在应用
Front Cell Dev Biol. 2021 Feb 22;9:639233. doi: 10.3389/fcell.2021.639233. eCollection 2021.
2
Non-blood sources of cell-free DNA for cancer molecular profiling in clinical pathology and oncology.非血液游离 DNA 作为临床病理学和肿瘤学中癌症分子谱分析的替代样本来源。
Crit Rev Oncol Hematol. 2019 Sep;141:36-42. doi: 10.1016/j.critrevonc.2019.06.005. Epub 2019 Jun 7.
3
Liquid biopsy in early stage lung cancer.早期肺癌的液体活检
Transl Lung Cancer Res. 2016 Oct;5(5):517-524. doi: 10.21037/tlcr.2016.10.15.
4
The role of circulating free DNA in the management of NSCLC.循环游离 DNA 在 NSCLC 管理中的作用。
Expert Rev Anticancer Ther. 2019 Jan;19(1):19-28. doi: 10.1080/14737140.2019.1548938. Epub 2018 Nov 29.
5
Cell-Free DNA in the Management of Colorectal Cancer.游离DNA在结直肠癌管理中的应用
Recent Results Cancer Res. 2020;215:253-261. doi: 10.1007/978-3-030-26439-0_13.
6
Liquid biopsy and PCR-free ultrasensitive detection systems in oncology (Review).液体活检和无 PCR 超灵敏检测系统在肿瘤学中的应用（综述）。
Int J Oncol. 2018 Oct;53(4):1395-1434. doi: 10.3892/ijo.2018.4516. Epub 2018 Aug 6.
7
Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases.无细胞游离 DNA：在肾脏病的病理生理学和生物标志物中的作用。
Expert Rev Mol Med. 2018 Jan 18;20:e1. doi: 10.1017/erm.2017.12.
8
Using circulating cell-free DNA to monitor personalized cancer therapy.利用循环无细胞 DNA 监测个体化癌症治疗。
Crit Rev Clin Lab Sci. 2017 May;54(3):205-218. doi: 10.1080/10408363.2017.1299683. Epub 2017 Apr 10.
9
Toward the Development of a Circulating Free DNA-Based Diagnostic Test for Infectious Diseases: a Review of Evidence for Tuberculosis.迈向传染病循环游离 DNA 诊断检测的发展：结核病证据综述。
J Clin Microbiol. 2019 Mar 28;57(4). doi: 10.1128/JCM.01234-18. Print 2019 Apr.
10
Potential clinical applications of circulating cell-free DNA in ovarian cancer patients.循环游离 DNA 在卵巢癌患者中的潜在临床应用。
Expert Rev Mol Med. 2018 Dec 18;20:e6. doi: 10.1017/erm.2018.5.

引用本文的文献

1
The Quest for Non-Invasive Diagnosis: A Review of Liquid Biopsy in Glioblastoma.非侵入性诊断的探索：胶质母细胞瘤液体活检综述
Cancers (Basel). 2025 Aug 19;17(16):2700. doi: 10.3390/cancers17162700.
2
Liquid biopsy in breast cancer: Redefining precision medicine.乳腺癌中的液体活检：重新定义精准医学。
J Liq Biopsy. 2025 Jul 16;9:100312. doi: 10.1016/j.jlb.2025.100312. eCollection 2025 Sep.
3
Impact of Long-Term Plasma Storage on Cell-Free DNA Epigenetic Biomarker Studies.长期血浆储存对游离DNA表观遗传生物标志物研究的影响。

本文引用的文献

1
Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrin α2β1.低表达 miR-34c-3p 的外泌体通过上调整合素 α2β1 促进非小细胞肺癌的侵袭和迁移。
Signal Transduct Target Ther. 2020 Apr 22;5(1):39. doi: 10.1038/s41392-020-0133-y.
2
Molecular principles of metastasis: a hallmark of cancer revisited.转移的分子原理：重新审视癌症的一个标志
Signal Transduct Target Ther. 2020 Mar 12;5(1):28. doi: 10.1038/s41392-020-0134-x.
3
Long-noncoding RNAs (lncRNAs) in drug metabolism and disposition, implications in cancer chemo-resistance.
Biomolecules. 2025 Jun 25;15(7):927. doi: 10.3390/biom15070927.
4
Review of Plasma Exosomal DNA for Detecting EGFR Mutations in Non-Small Cell Lung Cancer (NSCLC).血浆外泌体DNA用于检测非小细胞肺癌（NSCLC）中表皮生长因子受体（EGFR）突变的综述
Adv Biomed Res. 2025 Apr 30;14:39. doi: 10.4103/abr.abr_640_24. eCollection 2025.
5
The Art (and Science) of Individualized Selection of Non-Invasive Prenatal Screening (NIPS).非侵入性产前筛查（NIPS）个体化选择的艺术（与科学）
Int J Womens Health. 2025 May 7;17:1271-1283. doi: 10.2147/IJWH.S437214. eCollection 2025.
6
Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling in the ES-2 Ovarian Carcinoma Cell Line, Influencing Cell Proliferation, Quiescence, and Chemoresistance in a Cell-of-Origin-Specific Manner.游离DNA（cfDNA）调节ES-2卵巢癌细胞系中的代谢重塑，以细胞起源特异性方式影响细胞增殖、静止和化疗耐药性。
Metabolites. 2025 Apr 2;15(4):244. doi: 10.3390/metabo15040244.
7
Cell-Free DNA (cfDNA) Regulates Metabolic Remodeling, Sustaining Proliferation, Quiescence, and Migration in MDA-MB-231, a Triple-Negative Breast Carcinoma (TNBC) Cell Line.游离DNA（cfDNA）调节三阴性乳腺癌（TNBC）细胞系MDA-MB-231中的代谢重塑、维持增殖、静止和迁移。
Metabolites. 2025 Mar 27;15(4):227. doi: 10.3390/metabo15040227.
8
Relative mtDNA copy number in embryo spent culture medium is not a reliable biomarker of human embryo aneuploidy.胚胎培养液中的相对线粒体DNA拷贝数并非人类胚胎非整倍体的可靠生物标志物。
Reprod Fertil. 2025 Apr 29;6(2). doi: 10.1530/RAF-25-0001. Print 2025 Apr 1.
9
Deciphering the interplay: circulating cell-free DNA, signaling pathways, and disease progression in idiopathic pulmonary fibrosis.解读相互作用：循环游离DNA、信号通路与特发性肺纤维化的疾病进展
3 Biotech. 2025 Apr;15(4):102. doi: 10.1007/s13205-025-04272-y. Epub 2025 Mar 29.
10
Advancements in pathology: Digital transformation, precision medicine, and beyond.病理学的进展：数字转型、精准医学及其他。
J Pathol Inform. 2024 Nov 19;16:100408. doi: 10.1016/j.jpi.2024.100408. eCollection 2025 Jan.
长链非编码RNA（lncRNAs）在药物代谢与处置中的作用及其对癌症化疗耐药性的影响
Acta Pharm Sin B. 2020 Jan;10(1):105-112. doi: 10.1016/j.apsb.2019.09.011. Epub 2019 Oct 19.
4
The emerging treatment landscape of targeted therapy in non-small-cell lung cancer.非小细胞肺癌靶向治疗的新兴治疗领域。
Signal Transduct Target Ther. 2019 Dec 17;4:61. doi: 10.1038/s41392-019-0099-9. eCollection 2019.
5
Targeted therapeutic options and future perspectives for HER2-positive breast cancer.针对 HER2 阳性乳腺癌的靶向治疗选择和未来展望。
Signal Transduct Target Ther. 2019 Sep 13;4:34. doi: 10.1038/s41392-019-0069-2. eCollection 2019.
6
Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory study from the SORAMIC trial.循环 DNA 作为晚期肝细胞癌患者的预后生物标志物：来自 SORAMIC 试验的转化探索性研究。
J Transl Med. 2019 Oct 1;17(1):328. doi: 10.1186/s12967-019-2079-9.
7
Targeted sequencing of plasma cell-free DNA to predict response to PD1 inhibitors in advanced non-small cell lung cancer.血浆游离 DNA 靶向测序预测晚期非小细胞肺癌对 PD1 抑制剂的反应。
Lung Cancer. 2019 Nov;137:1-6. doi: 10.1016/j.lungcan.2019.09.005. Epub 2019 Sep 6.
8
Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma.胃食管腺癌的循环肿瘤 DNA 测序分析。
Clin Cancer Res. 2019 Dec 1;25(23):7098-7112. doi: 10.1158/1078-0432.CCR-19-1704. Epub 2019 Aug 19.
9
Correlation between early dynamics in circulating tumour DNA and outcome from FOLFIRI treatment in metastatic colorectal cancer.循环肿瘤 DNA 早期动力学与转移性结直肠癌 FOLFIRI 治疗结果的相关性。
Sci Rep. 2019 Aug 8;9(1):11542. doi: 10.1038/s41598-019-47708-1.
10
Updated developments on molecular imaging and therapeutic strategies directed against necrosis.针对坏死的分子成像与治疗策略的最新进展
Acta Pharm Sin B. 2019 May;9(3):455-468. doi: 10.1016/j.apsb.2019.02.002. Epub 2019 Feb 13.