The Art (and Science) of Individualized Selection of Non-Invasive Prenatal Screening (NIPS).

Non-invasive prenatal screening (NIPS), utilizing cell-free fetal DNA (cffDNA), has revolutionized prenatal care, transitioning from primarily detecting common fetal aneuploidies to encompassing detection of an increasingly broader spectrum of autosomal dominant and recessive conditions. This Commentary delves into the evolution of NIPS, emphasizes the importance of individualized selection of NIPS strategies based on specific clinical scenarios including patient characteristics, and explores its applications beyond aneuploidy screening. The optimal NIPS strategy should be carefully selected based on individual patient factors, including the specific clinical indications, maternal characteristics such as BMI, medical history, medication use, history of previous pregnancies, fetal characteristics such as multiple gestation or suspected anomalies, and the available NIPS technologies. There are also considerations in choosing between MPSS and SNP-based NIPS based cfDNA screening technologies. NIPS is a screening test; hence, diagnostic testing remains crucial for confirmation of any abnormal screening results. Notwithstanding, NIPS has significantly transformed prenatal care, offering valuable insights into fetal health and enabling earlier identification of potential risks. By carefully considering individual patient factors and selecting the most appropriate NIPS strategy, clinicians have the ability to maximize the benefits of this innovative technology while minimizing potential limitations. Continued research and technological advancements will further refine NIPS and expand its applications in the future.