动态运动心脏康复增加心脏病患者外周血中多能分化应激耐受细胞数量。

Minatoguchi Shingo, Ando Takahiro, Tanaka Toshiki, Yamada Yoshihisa, Kanamori Hiromitsu, Kawasaki Masanori, Nishigaki Kazuhiko, Minatoguchi Shinya

Department of Cardiology, Gifu University Graduate School of Medicine Gifu Japan.

Cardiology, Gifu Municipal Hospital Gifu Japan.

Circ Rep. 2018 Dec 8;1(1):17-19. doi: 10.1253/circrep.CR-18-0003.

It is still unclear whether dynamic exercise increases the number of Muse cells, pluripotent stem cells, in the peripheral blood. The number of Muse cells, SSEA3 and CD105 double-positive cells, in the peripheral blood was measured using FACS before and after 40 min of cardiac rehabilitation with dynamic exercise in 6 patients with heart disease. The number of Muse cells significantly increased after cardiac rehabilitation in all patients. Muse cell mobilization may be related to the beneficial clinical outcome of cardiac rehabilitation. Cardiac rehabilitation increases the number of Muse cells in the peripheral blood.

动态运动是否会增加外周血中多能干细胞——多潜能非对称性干细胞（Muse细胞）的数量仍不清楚。在6例心脏病患者进行40分钟动态运动心脏康复前后，使用荧光激活细胞分选术（FACS）测量外周血中Muse细胞（阶段特异性胚胎抗原-3（SSEA3）和CD105双阳性细胞）的数量。所有患者心脏康复后，Muse细胞数量显著增加。Muse细胞动员可能与心脏康复的有益临床结果有关。心脏康复可增加外周血中Muse细胞的数量。