Department of Cell & Developmental Biology, and the Rocky Mountain Taste & Smell Center, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, Mail Stop 8108, Aurora, CO 80045, USA.
Chem Senses. 2021 Jan 1;46. doi: 10.1093/chemse/bjab011.
Since the early 20th century, progress in cancer therapies has significantly improved disease prognosis. Nonetheless, cancer treatments are often associated with side effects that can negatively affect patient well-being and disrupt the course of treatment. Among the main side effects, taste impairment is associated with depression, malnutrition, and morbid weight loss. Although relatively common, taste disruption associated with cancer therapies remains poorly understood. Here, we review the current knowledge related to the molecular mechanisms underlying taste maintenance and disruption in the context of cancer therapies.
自 20 世纪初以来，癌症治疗的进展显著改善了疾病的预后。尽管如此，癌症治疗常常伴随着副作用，这些副作用会对患者的健康产生负面影响，并打乱治疗进程。在主要的副作用中，味觉障碍与抑郁、营养不良和病态体重减轻有关。尽管味觉障碍在癌症治疗中相对常见，但人们对其相关的分子机制仍知之甚少。在这里，我们综述了与癌症治疗相关的味觉维持和破坏的分子机制的现有知识。
