对85名怀孕的问题饮酒者进行酒精咨询：对饮酒及胎儿结局的影响。
Alcohol counselling of 85 pregnant problem drinkers: effect on drinking and fetal outcome.
作者信息
Halmesmäki E
机构信息
Department of Obstetrics and Gynaecology, University Central Hospital, Helsinki, Finland.
出版信息
Br J Obstet Gynaecol. 1988 Mar;95(3):243-7.
Eighty-five pregnant problem drinkers were given intensive counselling throughout gestation to persuade them to reduce or stop their alcohol intake. Nevertheless, 7% of their blood specimens collected at follow-up visits contained ethanol. Fifty-five women (65%) were able to reduce their alcohol consumption by at least 50%. Alcohol abuse was associated in a dose-dependent manner with fetal growth retardation detectable by ultrasonography from 27 weeks gestation. Twenty infants (24%) had a complete fetal alcohol syndrome and 22 (26%) had some features of 'fetal alcohol effects' (FAE). In addition, the rate of structural malformations was high (13%). Of the women with continuous alcohol abuse 89% gave birth to infants with at least one feature of FAE compared with only 40% of those who decreased their alcohol consumption.
八十五名孕期酗酒者在整个孕期都接受了强化咨询，以劝其减少或停止饮酒。然而，在随访时采集的血液样本中，7%含有乙醇。五十五名女性（65%）能够将饮酒量至少减少50%。从妊娠27周起，超声检查可检测到酒精滥用与胎儿生长受限呈剂量依赖性相关。二十名婴儿（24%）患有完全性胎儿酒精综合征，22名（26%）有“胎儿酒精影响”（FAE）的一些特征。此外，结构畸形的发生率很高（13%）。持续酗酒的女性中，89%生下的婴儿至少有一项FAE特征，而饮酒量减少的女性中这一比例仅为40%。
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