State Key Laboratory of Microbial Resources, CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China.
University of Chinese Academy of Sciences, 100049 Beijing, China.
Nat Prod Rep. 2021 Oct 20;38(10):1887-1909. doi: 10.1039/d0np00075b.
Covering: up to 2020Glycosylated natural products hold great potential as drugs for the treatment of human and animal diseases. Heptoses, known as seven-carbon-chain-containing sugars, are a group of saccharides that are rarely observed in natural products. Based on the structures of the heptoses, the heptose-containing natural products can be divided into four groups, characterized by heptofuranose, highly-reduced heptopyranose, D-heptopyranose, and L-heptopyranose. Many of them possess remarkable biological properties, including antibacterial, antifungal, antitumor, and pain relief activities, thereby attracting great interest in biosynthesis and chemical synthesis studies to understand their construction mechanisms and structure-activity relationships. In this review, we summarize the structural properties, biological activities, and recent progress in the biosynthesis of bacterial natural products featuring seven-carbon-chain-containing sugars. The biosynthetic origins of the heptose moieties are emphasized.
截至 2020 年，糖基天然产物具有巨大的潜力，可作为治疗人类和动物疾病的药物。庚糖是一类在天然产物中很少观察到的含有七个碳原子的糖。根据庚糖的结构，庚糖天然产物可分为四类，分别以庚呋喃糖、高度还原的庚吡喃糖、D-庚吡喃糖和 L-庚吡喃糖为特征。它们中的许多具有显著的生物活性，包括抗菌、抗真菌、抗肿瘤和止痛活性，因此引起了人们对生物合成和化学合成研究的极大兴趣，以了解它们的构建机制和结构-活性关系。在这篇综述中，我们总结了具有七碳链的细菌天然产物的结构特性、生物活性和生物合成研究的最新进展。强调了庚糖部分的生物合成起源。
