抗阻训练与卵巢癌风险的关联。
The association of resistance training with risk of ovarian cancer.
机构信息
Department of Gynecologic Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Department of Obstetrics & Gynecology, University of South Florida, Tampa, FL, USA.
出版信息
Cancer Med. 2021 Apr;10(7):2489-2495. doi: 10.1002/cam4.3804. Epub 2021 Mar 11.
BACKGROUND
Increasing evidence, including multiple putative inflammatory risk factors (e.g., c-reactive protein, and adiposity), supports that inflammation plays an important role in ovarian carcinogenesis. Resistance training (RT) is associated with lower levels of circulating inflammatory markers, independent of physical activity.
METHODS
We evaluated the relationship between RT and risk of ovarian cancer accounting for other physical activity (e.g., walking) in two large prospective cohorts, the Nurses' Health Study (NHS) and NHSII.
KEY RESULTS
In total, analyses included 42,005 NHS participants (2000-2016) and 67,289 NHSII participants (2001-2017) with RT assessed every 4 years. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of RT with ovarian cancer risk overall and by tumor subtype, adjusting for known and putative ovarian cancer risk factors. We identified a total of 609 cases over 1,748,884 person-years. No association was observed with overall ovarian cancer risk (RT ≥60 vs 0 min/wk, HR = 0.95, 95%CI: 0.74-1.22) or by histotype (comparable HR = 0.86 and 0.98 for type I and II tumors, respectively). Results did not differ by body mass index (Pinteraction = 0.97), or other physical activity (Pinteraction = 0.31).
CONCLUSIONS & INFERENCES: We observed no evidence that moderate levels of RT were associated with risk of ovarian cancer. Further investigations are required to confirm these findings.
背景
越来越多的证据表明，炎症在卵巢癌的发生中起着重要作用，其中包括多种潜在的炎症危险因素（例如 C 反应蛋白和肥胖）。阻力训练（RT）与循环炎症标志物水平降低有关，且与体力活动无关。
方法
我们在两项大型前瞻性队列研究（护士健康研究（NHS）和 NHSII）中，评估了 RT 与卵巢癌风险的关系，同时考虑了其他体力活动（例如步行）。
主要结果
共纳入 NHS 参与者 42005 例（2000-2016 年）和 NHSII 参与者 67289 例（2001-2017 年），每 4 年评估一次 RT。多变量 Cox 比例风险模型用于估计 RT 与卵巢癌风险的总体风险比（HR）和 95%置信区间（CI），同时调整已知和潜在的卵巢癌风险因素。在 1748884 人年的随访中，共发生 609 例卵巢癌。RT 与卵巢癌总体风险无关联（RT≥60 与 0 分钟/周相比，HR=0.95，95%CI：0.74-1.22）或与组织学类型有关（I 型和 II 型肿瘤的可比 HR 分别为 0.86 和 0.98）。结果不因 BMI（P 交互=0.97）或其他体力活动（P 交互=0.31）而异。
结论
我们没有发现中等强度 RT 与卵巢癌风险相关的证据。需要进一步的研究来证实这些发现。
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