Kasting N W
Department of Physiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Can J Physiol Pharmacol. 1988 Jan;66(1):22-6. doi: 10.1139/y88-004.
The relative dependence or independence of the secretion of the neurohypophysial hormones, arginine vasopressin and oxytocin, was investigated using a wide variety of stimuli reported to cause the secretion of one or the other hormone. Differences in species, animal preparations, sampling techniques, assays, and other factors make comparison of many previous studies difficult. The aim of this study was to overcome these problems by using the same methodology, animal species, and assays to compare vasopressin and oxytocin release. To further strengthen the analysis, determinations of vasopressin and oxytocin were done in the same blood samples. The results demonstrated that during simultaneous release of both hormones, vasopressin is released in greater proportion following restraint stress, hemorrhage, isotonic hypovolemia, and nicotine, whereas oxytocin is released in greater proportion following endotoxin or hypertonic saline. Vasopressin was released without oxytocin following diethylstilbestrol. Oxytocin was released without concomitant vasopressin release following exercise, hypothermia, hyperthermia, labour, and lactation. Neither oxytocin nor vasopressin release was observed following thyroid-releasing hormone or insulin-induced hypoglycemia. These data illustrate the marked flexibility of the hypothalamo-neurohypophysial system that regulates secretion of vasopressin and oxytocin.
利用多种据报道可引起神经垂体激素之一分泌的刺激因素，对神经垂体激素精氨酸加压素和催产素分泌的相对依赖性或独立性进行了研究。物种、动物制备方法、采样技术、检测方法及其他因素的差异使得以往许多研究之间难以进行比较。本研究的目的是通过使用相同的方法、动物物种和检测方法来比较加压素和催产素的释放，以克服这些问题。为了进一步加强分析，在相同的血样中测定加压素和催产素。结果表明，在两种激素同时释放时，在束缚应激、出血、等渗性血容量减少和尼古丁作用后，加压素释放的比例更大，而在内毒素或高渗盐水作用后，催产素释放的比例更大。己烯雌酚作用后，加压素单独释放，无催产素释放。运动、体温过低、体温过高、分娩和哺乳后，催产素单独释放，无加压素伴随释放。促甲状腺激素或胰岛素诱导的低血糖后，未观察到催产素或加压素释放。这些数据说明了调节加压素和催产素分泌的下丘脑-神经垂体系统具有显著的灵活性。
