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八种分枝杆菌属菌种的流行病学风险因素及地理分布

Epidemiological risk factors and the geographical distribution of eight Mycobacterium species.

作者信息

Donohue Maura J

机构信息

United States Environmental Protection Agency, Office of Research and Development, Center of Environmental Solutions and Emergency Response (CESER), 26 W. Martin Luther King Dr. Mail Stop 587, Cincinnati, OH, 45268, USA.

出版信息

BMC Infect Dis. 2021 Mar 12;21(1):258. doi: 10.1186/s12879-021-05925-y.

DOI:10.1186/s12879-021-05925-y
PMID:33706712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7953749/
Abstract

BACKGROUND

Nontuberculous mycobacteria (NTM) are environmental bacterium that may cause and/or compound respiratory diseases in humans. There are over a hundred NTM species with varying pathogenicity's Therefore, it is necessary to characterize the populations at risk for each species.

METHODS

Demographic (age, sex, and state of residence) and microbiological data from 2014 were extracted from Mississippi, Missouri, and Ohio disease surveillance systems. NTM species with > 50 reports were included in the analysis. Patient sex, age, and incidence rates were generated for each of the following NTM species: M. abscessus, M. avium complex (MAC), M. chelonae, M. fortuitum, M. gordonae, M. kansasii, M. mucogenicum, and M. peregrinum.

RESULTS

Analysis by sex showed that M. chelonae,M. fortuitum, M. gordonae,and M. kansasii had significantly higher rates in males than females. Age was not associated with patient rates for several specific NTM species e.g., M. chelonae. Mississippi had the highest patient' rates for M. avium, M. gordonae, M. kansasii, and M. chelonae. Ohio had the highest patient' rates for M. abscessus, M. mucogenicum, and M. peregrinum. The highest patient's rate for M. fortuitum was observed in Missouri.

CONCLUSION

This study showed that NTM infection occurred more frequently in males. The highest rates were observed in Mississippi for most of the NTMs studied. Age was not a strong risk factor for some of the NTM species.

摘要

背景

非结核分枝杆菌（NTM）是一种环境细菌，可能导致和/或加重人类的呼吸道疾病。有超过一百种NTM菌种，其致病性各不相同。因此，有必要对每种菌种的高危人群进行特征描述。

方法

从密西西比州、密苏里州和俄亥俄州的疾病监测系统中提取2014年的人口统计学数据（年龄、性别和居住州）和微生物学数据。分析纳入报告数超过50例的NTM菌种。针对以下每种NTM菌种计算患者的性别、年龄和发病率：脓肿分枝杆菌、鸟分枝杆菌复合群（MAC）、龟分枝杆菌、偶发分枝杆菌、戈登分枝杆菌、堪萨斯分枝杆菌、产黏液分枝杆菌和 Peregrinum分枝杆菌。

结果

按性别分析显示，龟分枝杆菌、偶发分枝杆菌、戈登分枝杆菌和堪萨斯分枝杆菌在男性中的发病率显著高于女性。年龄与几种特定NTM菌种的患者发病率无关，例如龟分枝杆菌。密西西比州鸟分枝杆菌、戈登分枝杆菌、堪萨斯分枝杆菌和龟分枝杆菌的患者发病率最高。俄亥俄州脓肿分枝杆菌、产黏液分枝杆菌和 Peregrinum分枝杆菌的患者发病率最高。在密苏里州观察到偶发分枝杆菌的患者发病率最高。

结论

本研究表明，NTM感染在男性中更常见。在所研究的大多数NTM菌种中，密西西比州的发病率最高。年龄对某些NTM菌种不是一个强有力的风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb73/7953749/160071f9de4a/12879_2021_5925_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb73/7953749/4dbfb7786fd6/12879_2021_5925_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb73/7953749/160071f9de4a/12879_2021_5925_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb73/7953749/4dbfb7786fd6/12879_2021_5925_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb73/7953749/e79d70eb936b/12879_2021_5925_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb73/7953749/ab068705a1a3/12879_2021_5925_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb73/7953749/c9ad427f622d/12879_2021_5925_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb73/7953749/160071f9de4a/12879_2021_5925_Fig5_HTML.jpg

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