Alakus Mehmet Fuat, Caglayan Mehtap, Ekin Nazım, Oncul Hasan, Arac Esref, Dag Umut, Diri Halit
Department of Ophthalmology, University of Health Sciences, Diyarbakir Gazi Yasargil Research and Training Hospital, Diyarbakır, Turkey.
Department of Internal Medicine, University of Health Sciences, Diyarbakir Gazi Yasargil Research and Training Hospital, Diyarbakır, Turkey.
Eye Vis (Lond). 2021 Mar 11;8(1):8. doi: 10.1186/s40662-021-00231-9.
To investigate the topographic measurements and densitometry of corneas in Wilson's disease (WD) patients with or without a Kayser-Fleischer ring (KF-r) compared to healthy individuals.
This cross-sectional study included 20 WD patients without a KF-r (group I), 18 WD patients with a KF-r (group II), and 20 age-matched controls (group III). The Pentacam high resolution imaging system is used to determine corneal topographic measurements and densitometry.
Mean age for groups I, II and III was 25.40 ± 6.43 years (14-36 years), 25.38 ± 6.96 years (16-39 years), 23.60 ± 6.56 years (17-35 years), respectively (P = 0.623). There was no significant difference between the groups in terms of the anterior corneal densitometry values (P > 0.05), while the 6-10 mm and 10-12 mm mid stroma and the 2-6 mm, 6-10 mm, and 10-12 mm posterior corneal densitometry values in group II were significantly higher than those in groups I and III (for all values, P < 0.05). However, the 10-12 mm posterior corneal densitometry values in group I were also significantly higher than those in group III (P = 0.038). The central corneal thickness (CCT), thinnest corneal thickness (tCT), and corneal volume (CV) values in groups I and II were significantly lower than those in group III (for CCT values, P = 0.011 and P = 0.009; for tCT values, P = 0.010 and P = 0.005; for CV values, P = 0.043 and P = 0.029).
In WD patients with a KF-r, corneal transparency decreased in the peripheral posterior and mid stromal corneal layers; for these patients, corneal transparency may be impaired not only in the peripheral cornea but also in the paracentral cornea.
比较有或没有凯-费环（KF环）的肝豆状核变性（WD）患者与健康个体的角膜地形图测量和密度测定结果。
这项横断面研究纳入了20例无KF环的WD患者（I组）、18例有KF环的WD患者（II组）和20例年龄匹配的对照组（III组）。使用Pentacam高分辨率成像系统确定角膜地形图测量和密度测定结果。
I组、II组和III组的平均年龄分别为25.40±6.43岁（14 - 36岁）、25.38±6.96岁（16 - 39岁）、23.60±6.56岁（17 - 35岁）（P = 0.623）。各组之间角膜前表面密度测定值无显著差异（P > 0.05），而II组角膜基质中层6 - 10mm和10 - 12mm以及角膜后表面2 - 6mm、6 - 10mm和10 - 12mm的密度测定值显著高于I组和III组（所有值，P < 0.05）。然而，I组角膜后表面10 - 12mm的密度测定值也显著高于III组（P = 0.038）。I组和II组的中央角膜厚度（CCT）、最薄角膜厚度（tCT）和角膜体积（CV）值显著低于III组（CCT值，P = 0.011和P = 0.009；tCT值，P = 0.010和P = 0.005；CV值，P = 0.043和P = 0.029）。
在有KF环的WD患者中，角膜周边后层和基质中层的透明度降低；对于这些患者，角膜透明度可能不仅在周边角膜受损，而且在旁中央角膜也受损。
