Yuan Jiajun, Qian Han, Cao Shiyan, Dong Bin, Yan Xiaoyu, Luo Shuanghong, Zhou Min, Zhou Sha, Ning Botao, Zhao Liebin
Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Children Health Advocacy Institute, China Hospital Development Institute of Shanghai Jiao Tong University, Shanghai, China.
Transl Pediatr. 2021 Feb;10(2):423-434. doi: 10.21037/tp-20-144.
In order to investigate the clinical features of pregnant women and their neonates with coronavirus disease 2019 (COVID-19) and the evidence of vertical transmission of COVID-19, we retrieved studies included in PubMed, Medline and Chinese databases from January 1, 2000 to October 25, 2020 using relevant terms, such as 'COVID-19', 'vertical transmission' . in 'Title/Abstract'. Case reports and case series were included according to the inclusion and exclusion criteria. We conducted literature screening and data extraction, and performed literature bias risk assessment. Total of 13 case series and 16 case reports were collected, including a total of 564 pregnant women with COVID-19 and their 555 neonates, of which 549 neonates received nucleic acid test for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 18 neonates was diagnosed with COVID-19. The positive rate is 3.28%. Amniotic fluid of one woman was tested positive for SARS-CoV-2. The majority of infected neonates were born under strict infection control and received isolation and artificial feeding. Up till now, there is no sufficient evidence to exclude the possibility of vertical transmission for COVID-19 based on the current available data.
为了调查2019冠状病毒病（COVID-19）孕妇及其新生儿的临床特征以及COVID-19垂直传播的证据，我们使用“COVID-19”“垂直传播”等相关术语，在标题/摘要中检索了2000年1月1日至2020年10月25日期间PubMed、Medline和中文数据库中收录的研究。根据纳入和排除标准纳入病例报告和病例系列。我们进行了文献筛选和数据提取，并进行了文献偏倚风险评估。共收集到13个病例系列和16篇病例报告，包括564例COVID-19孕妇及其555例新生儿，其中549例新生儿接受了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）核酸检测，18例新生儿被诊断为COVID-19。阳性率为3.28%。1名女性的羊水SARS-CoV-2检测呈阳性。大多数受感染新生儿在严格的感染控制下出生，并接受隔离和人工喂养。截至目前，根据现有数据，尚无充分证据排除COVID-19垂直传播的可能性。
