Singh Swati, Mankotia Dipanker Singh, Shankar Kepeemadam Balasubramanyam, Siraj Fouzia
Department of Pathology, ICMR-National Institute of Pathology, New Delhi, India.
Department of Neurosurgery, VMMC and Safdarjung Hospital, New Delhi, India.
Asian J Neurosurg. 2020 Dec 21;15(4):1091-1095. doi: 10.4103/ajns.AJNS_188_20. eCollection 2020 Oct-Dec.
Giant cell tumors (GCT) are generally benign, commonly affecting young adults, with a slight preponderance in females. They are locally aggressive with a high rate of local recurrence. Most of them are found in the epiphysis of long bones, making the base of the skull a rare site. We report the case of a 35-year-old female, who presented with neurological symptoms of headache and diplopia. On magnetic resonance imaging, a space-occupying lesion was discovered in the clivus. Histopathology was diagnostic of a GCT. GCT arising from the clivus is extremely uncommon, with about 15 cases published in the literature. The present case highlights the rarity of this tumor and contributes to the existing literature with analysis and evaluation of the management strategies and prognosis.
骨巨细胞瘤（GCT）通常为良性，常见于年轻人，女性略多。它们具有局部侵袭性，局部复发率很高。大多数病例发生在长骨的骨骺，因此颅底是罕见的发病部位。我们报告一例35岁女性病例，该患者出现头痛和复视等神经症状。磁共振成像检查发现斜坡有占位性病变。组织病理学诊断为骨巨细胞瘤。起源于斜坡的骨巨细胞瘤极为罕见，文献中报道约15例。本病例突出了该肿瘤的罕见性，并通过对治疗策略和预后的分析与评估为现有文献做出了贡献。
