Khan Suliman, Zeb Falak, Shoaib Muhammad, Nabi Ghulam, Ul Haq Ijaz, Xu Kang, Li Hui
Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.
Department of Cerebrovascular Diseases, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Iran J Public Health. 2020 Nov;49(11):2032-2043. doi: 10.18502/ijph.v49i11.4717.
The coronavirus disease-19 (COVID-19) negatively affects immune system. It is linked with adverse pregnancy outcomes. These complications may be linked with the infections mediated deficiency of micronutrients in pregnant women. COVID-19 cause's malabsorption of micronutrients thereby increases the risk of their deficiency. Both micronutrients deficiencies and poor micronutrients intake can compromise immune function and may increase the risk of pregnancy complications associated with COVID-19 infection. Vita-min A, C, D, E, and selected minerals iron (Fe), selenium (Se), and zinc (Zn) are the micronutrients essential for immuno-competency and play a significant role in the prevention of adverse pregnancy outcomes. Immune function and pregnancy outcomes can be improved by adequate intake of micronutrients in diet or in supplements form. Based on regulatory links between viral infection, micronutrients, immunity, and pregnancy outcomes, this review highlights the role of micronutrients in boosting immunity to reduce or prevent pregnancy complications in COVID-19 infected women.
新型冠状病毒肺炎（COVID-19）会对免疫系统产生负面影响。它与不良妊娠结局有关。这些并发症可能与孕妇体内感染介导的微量营养素缺乏有关。COVID-19会导致微量营养素吸收不良，从而增加其缺乏的风险。微量营养素缺乏和微量营养素摄入不足都会损害免疫功能，并可能增加与COVID-19感染相关的妊娠并发症风险。维生素A、C、D、E以及特定矿物质铁（Fe）、硒（Se）和锌（Zn）是免疫能力所必需的微量营养素，在预防不良妊娠结局中发挥着重要作用。通过在饮食中或补充剂形式中充分摄入微量营养素，可以改善免疫功能和妊娠结局。基于病毒感染、微量营养素、免疫和妊娠结局之间的调节联系，本综述强调了微量营养素在增强免疫力以减少或预防COVID-19感染女性妊娠并发症方面的作用。
