新冠病毒是否会从其他冠状病毒中获得增强效应？
Is COVID-19 receiving ADE from other coronaviruses?
机构信息
College of Biological Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.
出版信息
Microbes Infect. 2020 Mar;22(2):72-73. doi: 10.1016/j.micinf.2020.02.006. Epub 2020 Feb 22.
Abstract
One of the most perplexing questions regarding the current COVID-19 coronavirus epidemic is the discrepancy between the severity of cases observed in the Hubei province of China and those occurring elsewhere in the world. One possible answer is antibody dependent enhancement (ADE) of SARS-CoV-2 due to prior exposure to other coronaviruses. ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses, making it a possible explanation for the observed geographic limitation of severe cases and deaths.
摘要
目前 COVID-19 冠状病毒流行中最令人费解的问题之一是中国湖北省观察到的病例严重程度与世界其他地区的病例严重程度之间的差异。一种可能的解释是由于先前接触其他冠状病毒，导致 SARS-CoV-2 的抗体依赖性增强（ADE）。ADE 调节免疫反应，并可引发持续的炎症、淋巴细胞减少症和/或细胞因子风暴，这些在严重病例和死亡中均有记录。ADE 还需要先前接触类似的抗原表位，推测存在于当地病毒中，这使其成为观察到的严重病例和死亡的地理局限性的一个可能解释。
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