人体游离红细胞镁浓度的31P核磁共振测量及其与血压的关系。

31P nuclear magnetic resonance measurement of free erythrocyte magnesium concentration in man and its relation to blood pressure.

Woods K L, Walmsley D, Heagerty A M, Turner D L, Lian L Y

Department of Pharmacology and Therapeutics, University of Leicester, U.K.

Clin Sci (Lond). 1988 May;74(5):513-7. doi: 10.1042/cs0740513.

Abstract

31P n.m.r. spectroscopy was used to measure the dissociation constant of MgATP under simulated intracellular conditions and to measure erythrocyte free magnesium concentration. 2. In a group of 40 subjects, the relationship between erythrocyte free magnesium and blood pressure, age and sex was examined by univariate and multivariate regression analysis. 3. A weak positive association was found between erythrocyte free magnesium and mean blood pressure. This association was lost in a multivariate regression analysis including both age and sex. 4. No significant relationship was found between erythrocyte free magnesium and age, sex, family history of hypertension or use of the combined oral contraceptive pill in the sample studied.

摘要

采用31P核磁共振光谱法在模拟细胞内环境下测量MgATP的解离常数，并测量红细胞游离镁浓度。2. 在40名受试者组成的一组人群中，通过单变量和多变量回归分析研究红细胞游离镁与血压、年龄和性别的关系。3. 发现红细胞游离镁与平均血压之间存在微弱的正相关。在包括年龄和性别的多变量回归分析中，这种相关性消失了。4. 在本研究样本中，未发现红细胞游离镁与年龄、性别、高血压家族史或口服复方避孕药的使用之间存在显著关系。