Shibutani Y, Sakamoto K, Katsuno S, Yoshimoto S, Matsuura T
Department of Hygiene, Hyogo College of Medicine, Japan.
Acta Paediatr Scand. 1990 Mar;79(3):316-21. doi: 10.1111/j.1651-2227.1990.tb11463.x.
Serum and erythrocyte magnesium concentrations (S-Mg, E-Mg) were measured in 122 junior high school students followed up for two years from 12 to 14 years of age, and the relationship to blood pressure and a family history of hypertension were investigated. The subjects who had high S-Mg and E-Mg levels at the first examination two years prior tended to show high levels after this follow-up. There were significant positive correlations between two intraindividual values of S-Mg and E-Mg. A similar tendency was found for blood pressure. Tracking phenomena were observed with these measures. The subjects who had high E-Mg levels at the first examination showed no blood pressure elevation during the two-year period. The subjects with a family history of hypertension [FH(+)] showed a higher degree of blood pressure rise during two years than those with no family history [FH(-)], with a significant difference in systolic blood pressure at the age of 14. E-Mg tended to be lower in the FH(+) group than in the FH(-) group with a significant difference in 14-year-old girls. These results suggest that a hereditary predisposition to hypertension is related to magnesium metabolism and that intracellular magnesium deficiency may influence blood pressure elevation in the FH(+) children.
对122名12至14岁的初中生进行了为期两年的随访，测量了他们的血清和红细胞镁浓度（S-Mg、E-Mg），并研究了其与血压及高血压家族史的关系。两年前首次检查时S-Mg和E-Mg水平较高的受试者在此次随访后往往仍显示较高水平。S-Mg和E-Mg的两个个体内值之间存在显著正相关。血压也有类似趋势。这些指标观察到了追踪现象。首次检查时E-Mg水平较高的受试者在两年期间血压未升高。有高血压家族史[FH(+)]的受试者在两年内血压升高程度高于无家族史[FH(-)]的受试者，14岁时收缩压有显著差异。FH(+)组的E-Mg往往低于FH(-)组，14岁女孩中有显著差异。这些结果表明，高血压的遗传易感性与镁代谢有关，细胞内镁缺乏可能影响FH(+)儿童的血压升高。
