Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India.
J Drug Target. 2021 Nov;29(9):925-940. doi: 10.1080/1061186X.2021.1894436. Epub 2021 Mar 12.
Exosomes are membrane-based extracellular vesicles naturally released by the cells. Nano size range of exosomes and unique properties such as stability, biocompatibility and low immunogenicity are key parameters, which make them suitable as nanoparticulate drug delivery system and also considered as promising delivery carriers for future clinical use. This review outlines the composition, biogenesis, isolation and characterisation methods along with biological and clinical applications of exosomes. Further, the biopharmaceutical features of exosomes include loading method, modified exosomes and potential use of exosomes for different diseases are well explained with the current case studies. We well elaborate the future directions for clinical use of exosomes as drug delivery platforms.
外泌体是细胞自然释放的基于膜的细胞外囊泡。外泌体的纳米尺寸范围和独特性质，如稳定性、生物相容性和低免疫原性，是使其成为合适的纳米颗粒药物递送系统的关键参数，也被认为是未来临床应用有前途的递送载体。本综述概述了外泌体的组成、生物发生、分离和表征方法以及外泌体的生物学和临床应用。此外，外泌体的生物制药特性包括载药方法、修饰外泌体以及外泌体在不同疾病中的潜在用途，并结合当前的案例研究进行了详细说明。我们详细阐述了外泌体作为药物递送平台在临床应用中的未来方向。
