Vianna Fernanda Sales Luiz, Fraga Lucas Rosa, Abeche Alberto Mantovani, Silva André Anjos Da, Sanseverino Maria Teresa Vieira, Schuler-Faccini Lavinia
Universidade Federal do Rio Grande do Sul, Departamento de Genética, Programa de Pós-Graduação em Genética e Biologia Molecular, Porto Alegre, RS, Brazil.
Hospital de Clínicas de Porto Alegre, Sistema Nacional de Informações sobre Agentes Teratogênicos, Porto Alegre, RS, Brazil.
Genet Mol Biol. 2021 Mar 10;44(1 Suppl 1):e20200224. doi: 10.1590/1678-4685-GMB-2020-0224. eCollection 2021.
SARS-CoV-2 virus was first identified in the beginning of 2020 and has spread all over the world, causing the Coronavirus Disease 2019 (COVID-19) pandemic. The virus is a member of the Coronavirus family, which includes viruses that cause common cold, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). MERS and SARS are known by causing adverse events in pregnancy. Considering that SARS-CoV-2 is a new infection agent, little is known about the risk of its infection to human embryo/fetal development. However, SARS and MERS were associated with negative outcomes, such as miscarriage, preterm birth, intrauterine growth restriction and perinatal death. Here, we raise concerns and possibilities related the harmful potential of SARS-CoV-2 and COVID-19 to pregnancy, discussing symptoms, immunological changes during pregnancy, SARS-CoV-2 mutation rate (and the risks related to it). Finally, we point out recommendations to be performed by the scientific community and health care workers in order to identify and to manage potential risks to pregnant women and their babies.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）于2020年初首次被发现，并已在全球范围内传播，引发了2019冠状病毒病（COVID-19）大流行。该病毒是冠状病毒家族的成员，该家族包括导致普通感冒、中东呼吸综合征（MERS）和严重急性呼吸综合征（SARS）的病毒。已知MERS和SARS会在孕期引发不良事件。鉴于SARS-CoV-2是一种新型感染源，人们对其感染人类胚胎/胎儿发育的风险知之甚少。然而，SARS和MERS与不良结局相关，如流产、早产、胎儿生长受限和围产期死亡。在此，我们对SARS-CoV-2和COVID-19对妊娠的潜在危害提出担忧和可能性，讨论症状、孕期的免疫变化、SARS-CoV-2突变率（及其相关风险）。最后，我们指出科学界和医护人员应采取的建议，以识别和管理对孕妇及其婴儿的潜在风险。
