Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza, Egypt.
Department of Microbial Genetics, AGERI, ARC, Giza, Egypt.
Scand J Immunol. 2021 Jun;93(6):e13039. doi: 10.1111/sji.13039. Epub 2021 Mar 19.
COVID-19 is highly transmissible; however, its severity varies from one individual to another. Variability among different isolates of the virus and among its receptor (ACE2) may contribute to this severity, but comorbidity plays a major role on disease prognosis. Many comorbidities have been reported to be associated with severe COVID-19 patients. We have collected data from retrospective studies which include clinical and epidemiological features of patients and categorize them into severe/mild, ICU/non-ICU and survivors/dead patients. In this review, we give an update about SARS-CoV-2 structure with emphasis on the possible reasons for the severity of the virus in patients. We also collected information and patients' data to highlight the relation between COVID-19 patients and comorbidities.
新型冠状病毒（COVID-19）具有高度传染性，但个体之间的严重程度存在差异。病毒的不同分离株及其受体（ACE2）的变异性可能导致这种严重程度的差异，但合并症在疾病预后中起着主要作用。已经报道了许多合并症与重症 COVID-19 患者相关。我们从回顾性研究中收集了数据，其中包括患者的临床和流行病学特征，并将其分为重症/轻症、重症监护病房（ICU）/非 ICU 和幸存者/死亡患者。在这篇综述中，我们介绍了 SARS-CoV-2 的结构，并重点介绍了病毒在患者中引起严重程度的可能原因。我们还收集了信息和患者数据，以强调 COVID-19 患者与合并症之间的关系。
