Department of Conservative Dentistry & Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Poonamallee High Road, Chennai, Tamil Nadu, 600 077, India.
Carbohydr Polym. 2021 May 15;260:117774. doi: 10.1016/j.carbpol.2021.117774. Epub 2021 Feb 14.
3D printing, one of its kinds has been a recent technological trend to fabricate complex and patterned biomaterial with controlled precision. With the conventional kick-start of printing metals and plastics, advancements in printing viable cells, polysaccharides or microbes themselves have been achieved. The additive antimicrobial properties in bioinks sourced from organic and inorganic materials have profound implications in tissue engineering. Cellulose, alginate, exopolysaccharides, ceramics and synthetic polymers are integrated as a viable component in inks and used for bio-printing. To date, bacterial infection and immunogenicity pose a potential health risk during a tissue implant or bone substitution. In order to mitigate microbial infection, antimicrobial bioinks with significant antimicrobial potential have been the much sought after strategies. This approach could be an effective frontline defense against microbial interference in tissue engineering and biomedical applications. An overview on the antimicrobial potential of polysaccharides as bioinks for 3D bioprinting has been critically reviewed.
3D 打印是一种最近的技术趋势，可以制造具有控制精度的复杂和图案化的生物材料。随着传统的金属和塑料打印的启动，已经实现了可打印活细胞、多糖或微生物本身的进步。生物墨水的添加剂抗菌特性来源于有机和无机材料，对组织工程具有深远的意义。纤维素、藻酸盐、胞外多糖、陶瓷和合成聚合物作为一种可行的成分被整合到油墨中并用于生物打印。到目前为止，细菌感染和免疫原性在组织植入或骨替代过程中构成了潜在的健康风险。为了减轻微生物感染，具有显著抗菌潜力的抗菌生物墨水一直是备受追捧的策略。这种方法可能是对抗组织工程和生物医学应用中微生物干扰的有效第一道防线。本文综述了多糖作为 3D 生物打印生物墨水的抗菌潜力。
