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用于牙周组织再生的3D生物打印技术和生物墨水——文献综述

3D Bioprinting Techniques and Bioinks for Periodontal Tissues Regeneration-A Literature Review.

作者信息

Almeida Nátaly Domingues, Carneiro Camila Alves, de Marco Andrea Carvalho, Porto Vinicius Carvalho, França Rodrigo

机构信息

Department of Diagnosis and Surgery, University of the State of São Paulo, São José dos Campos 12200-000, SP, Brazil.

Dental Materials Research Lab, Department of Restorative Dentistry, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0W2, Canada.

出版信息

Biomimetics (Basel). 2024 Aug 9;9(8):480. doi: 10.3390/biomimetics9080480.

DOI:10.3390/biomimetics9080480
PMID:39194459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11352156/
Abstract

The periodontal tissue is made up of supporting tissues and among its functions, it promotes viscoelastic properties, proprioceptive sensors, and dental anchorage. Its progressive destruction by disease leads to the loss of bone and periodontal ligaments. For this reason, biomaterials are constantly being developed to restore tissue function. Various techniques are being used to promote regenerative dentistry, including 3D bioprinting with bioink formulations. This paper aims to review the different types of bioink formulations and 3D bioprinting techniques used in periodontal tissue regeneration. Different techniques have been formulated, and the addition of different materials into bioinks has been conducted, with the intention of improving the process and creating a bioink that supports cell viability, proliferation, differentiation, and stability for periodontal tissue regeneration.

摘要

牙周组织由支持组织构成,其功能包括促进黏弹性特性、本体感觉传感器功能以及牙齿固位。疾病对其进行性破坏会导致骨质和牙周韧带丧失。因此,人们不断研发生物材料以恢复组织功能。多种技术被用于促进再生牙科,包括使用生物墨水配方的3D生物打印。本文旨在综述牙周组织再生中使用的不同类型生物墨水配方和3D生物打印技术。已制定了不同技术,并向生物墨水中添加了不同材料,目的是改进该过程并制造出一种支持牙周组织再生的细胞活力、增殖、分化和稳定性的生物墨水。

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本文引用的文献

1
Unlocking the Future of Periodontal Regeneration: An Interdisciplinary Approach to Tissue Engineering and Advanced Therapeutics.开启牙周再生的未来:组织工程与先进治疗的跨学科方法。
Biomedicines. 2024 May 14;12(5):1090. doi: 10.3390/biomedicines12051090.
2
The Role of Cone Beam Computed Tomography in Periodontology: From 3D Models of Periodontal Defects to 3D-Printed Scaffolds.锥形束计算机断层扫描在牙周病学中的作用:从牙周缺损的三维模型到三维打印支架
J Pers Med. 2024 Feb 14;14(2):207. doi: 10.3390/jpm14020207.
3
3D bioprinting of microorganisms: principles and applications.
通过使用电纺聚己内酯/胶原蛋白/醋酸纤维素支架和负载姜黄素的ZIF-8纳米颗粒的胶原水凝胶递送牙周膜干细胞来增强牙周膜再生
Int J Nanomedicine. 2025 Jan 20;20:887-906. doi: 10.2147/IJN.S492274. eCollection 2025.
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Three-Dimensional Organotypic Systems for Modelling and Understanding Molecular Regulation of Oral Dentogingival Tissues.三维器官型系统用于模拟和理解口腔牙龈组织的分子调控。
Int J Mol Sci. 2024 Oct 28;25(21):11552. doi: 10.3390/ijms252111552.
微生物的 3D 生物打印:原理与应用。
Bioprocess Biosyst Eng. 2024 Apr;47(4):443-461. doi: 10.1007/s00449-023-02965-3. Epub 2024 Jan 31.
4
3D-printed bioink loading with stem cells and cellular vesicles for periodontitis-derived bone defect repair.3D 打印生物墨水负载干细胞和细胞囊泡用于牙周炎来源的骨缺损修复。
Biofabrication. 2024 Jan 31;16(2). doi: 10.1088/1758-5090/ad2081.
5
Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds.智能血管化3D/4D/5D/6D打印组织支架
Nanomicro Lett. 2023 Oct 31;15(1):239. doi: 10.1007/s40820-023-01187-2.
6
3D and 4D printing hydroxyapatite-based scaffolds for bone tissue engineering and regeneration.用于骨组织工程与再生的3D和4D打印羟基磷灰石基支架
Heliyon. 2023 Aug 22;9(9):e19363. doi: 10.1016/j.heliyon.2023.e19363. eCollection 2023 Sep.
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In Vitro and In Vivo Biological Assessments of 3D-Bioprinted Scaffolds for Dental Applications.用于牙科应用的 3D 生物打印支架的体外和体内生物学评估。
Int J Mol Sci. 2023 Aug 17;24(16):12881. doi: 10.3390/ijms241612881.
8
3D Bioprinting of a Bioactive Composite Scaffold for Cell Delivery in Periodontal Tissue Regeneration.三维生物打印用于牙周组织再生中细胞递送的生物活性复合支架。
Biomolecules. 2023 Jun 30;13(7):1062. doi: 10.3390/biom13071062.
9
Bioprinted PDLSCs with high-concentration GelMA hydrogels exhibit enhanced osteogenic differentiation in vitro and promote bone regeneration in vivo.高浓度 GelMA 水凝胶生物打印的 PDLCs 在体外表现出增强的成骨分化,并促进体内骨再生。
Clin Oral Investig. 2023 Sep;27(9):5153-5170. doi: 10.1007/s00784-023-05135-7. Epub 2023 Jul 10.
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3D-printed vascularized biofunctional scaffold for bone regeneration.用于骨再生的3D打印血管化生物功能支架
Int J Bioprint. 2023 Mar 8;9(3):702. doi: 10.18063/ijb.702. eCollection 2023.