异丙醇暴露对豚鼠鼻黏膜纤毛系统的毒性作用。

Toxicity of isopropyl alcohol exposure on the nasal mucociliary system in the guinea pig.

作者信息

Ohashi Y, Nakai Y, Koshimo H, Esaki Y, Ikeoka H, Horiguchi S, Teramoto K, Nakaseko H

机构信息

Department of Otolaryngology, Osaka City University Medical School, Japan.

出版信息

Environ Res. 1988 Jun;46(1):25-38. doi: 10.1016/s0013-9351(88)80056-2.

DOI:10.1016/s0013-9351(88)80056-2

PMID:3371290

Abstract

The toxicity of isopropyl alcohol (IPA) on the nasal mucosa in the guinea pig was experimentally studied, with special reference to the recovery process of the organ. The results showed that 400 ppm of IPA has an acute effect on the nasal mucosa and the recovery from such degeneration can occur in 2 weeks. When functional and morphological damages were induced by a higher level (5500 ppm) of IPA, it took over 2 weeks for complete recovery from such damage. The conclusion is that the present allowable level of IPA is reasonable from a viewpoint of the effect of short-term exposure to IPA on the nasal mucosa. In addition, a higher level of IPA exposure has a longer-term effect on the nasal mucociliary system in the guinea pig, and workers exposed to such a higher level of IPA should be given careful otolaryngological observation.

摘要

对豚鼠鼻黏膜异丙醇（IPA）的毒性进行了实验研究，特别关注该器官的恢复过程。结果表明，400 ppm的IPA对鼻黏膜有急性影响，这种变性的恢复可在2周内发生。当由较高浓度（5500 ppm）的IPA引起功能和形态损伤时，从这种损伤中完全恢复需要2周以上。结论是，从短期接触IPA对鼻黏膜的影响来看，目前IPA的允许水平是合理的。此外，较高水平的IPA暴露对豚鼠鼻黏液纤毛系统有长期影响，接触这种较高水平IPA的工人应接受仔细的耳鼻喉科观察。