Postgraduate Program in Public Health, Universidade Estadual de Londrina, Londrina, Brazil.
Health and Social Research Center, Universidad de Castilla-La Mancha, C/ Santa Teresa Jornet s/n, 16071, Cuenca, Spain.
Sleep Breath. 2021 Dec;25(4):2205-2212. doi: 10.1007/s11325-021-02343-x. Epub 2021 Mar 13.
Although polypharmacy is linked to health outcomes in the elderly, the use of multiple medications is increasing in middle-aged adults. This study analyzed whether or not the increased number of continuous-use medications (C-UM) is associated with objective and subjective sleep parameters in a working population.
Cross-sectional study with schoolteachers from public schools in Londrina, Brazil. The participants were classified according to the self-reported number of C-UM. Sleep data were obtained with actigraphy and a concomitant sleep diary for 7 days. The analyses were adjusted for socio-demographic, lifestyle, and morbidity variables.
A total of 17% of the participants were classified as using ≥3C-UM. In fully adjusted analyses, the use of ≥3C-UM was associated with lower actigraphic sleep duration (<6 h) (odds ratio [OR] = 2.51; 95% confidence interval [CI] = 1.01,6.21), higher actigraphic sleep onset latency (SOL) (OR = 2.65; 95%CI = 1.00,7.02), and with a higher number of awakenings during sleep measured by actigraphy (OR = 3.30; 95%CI = 1.32,8.28). The use of ≥3 C-UM was also associated with higher SOL (OR = 3.76; 95%CI = 1.36,10.5) and lower sleep efficiency (OR = 11.6; 95%CI = 2.92,46.1), as measured with the sleep diary. A 1-unit increment in the number of continuous-use medications was associated with higher self-reported SOL and lower subjective sleep efficiency.
The continuous use of ≥3 medications is associated with worse objective and subjective parameters of sleep duration and quality in schoolteachers.
尽管多种药物治疗与老年人的健康结果有关，但中年人使用多种药物的情况正在增加。本研究分析了在工作人群中，持续使用药物数量的增加是否与客观和主观睡眠参数相关。
这是一项在巴西隆德里纳市公立学校教师中进行的横断面研究。参与者根据自我报告的持续使用药物数量进行分类。使用活动记录仪和伴随的睡眠日记连续 7 天获取睡眠数据。分析结果调整了社会人口统计学、生活方式和发病情况等变量。
共有 17%的参与者被归类为使用≥3 种持续使用药物。在完全调整的分析中，使用≥3 种持续使用药物与较低的活动记录仪睡眠时间（<6 小时）（比值比 [OR] = 2.51；95%置信区间 [CI] = 1.01,6.21）、较高的活动记录仪睡眠潜伏期（SOL）（OR = 2.65；95%CI = 1.00,7.02）和通过活动记录仪测量的睡眠中更多觉醒次数（OR = 3.30；95%CI = 1.32,8.28）相关。使用≥3 种持续使用药物也与 SOL 较高（OR = 3.76；95%CI = 1.36,10.5）和睡眠效率较低（OR = 11.6；95%CI = 2.92,46.1）相关，这些参数通过睡眠日记测量。持续使用药物数量增加一个单位与自我报告的 SOL 增加和主观睡眠效率降低相关。
持续使用≥3 种药物与教师的客观和主观睡眠持续时间和质量参数较差相关。
