The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Department of Materials Science, Fudan University, Shanghai, 200433, P. R. China.
Macromol Rapid Commun. 2021 Sep;42(18):e2100022. doi: 10.1002/marc.202100022. Epub 2021 Mar 13.
Stimuli-responsive polymers undergo changes under different environmental conditions. Among them, phenylboronic acid (PBA) containing polymers (PBA-polymers) are unique, because they can selectively react with diols to generate borates that are sensitive to pH, sugars, and H O , and can be effectively used to synthesize smart drug carriers and self-healing hydrogels. Recently, multifunctional PBA-polymers (MF-PBA-polymers) have been developed using multicomponent reactions (MCRs) to introduce PBA groups into polymer structures. These MF-PBA-polymers have features similar to those of traditional PBA-polymers; moreover, they exhibit additional properties, such as fluorescence, antimicrobial activity, and antioxidant capability, when different MCRs are used. In this mini review, the preparation of these MF-PBA-polymers are summarized and the new properties/functions that have been introduced into these polymers using different MCRs are discussed. The uses of these MF-PBA-polymers as fluorescent cell anticoagulants, drug carriers, and gelators of functional self-healing hydrogels have been discussed. Additionally, the challenges encountered during their preparation are discussed and also the future developments in this field are touched upon.
刺激响应性聚合物在不同的环境条件下会发生变化。其中，含苯硼酸（PBA）的聚合物（PBA-聚合物）是独特的，因为它们可以选择性地与二醇反应生成硼酸酯，对 pH、糖和 H2O 敏感，并可有效用于合成智能药物载体和自修复水凝胶。最近，使用多组分反应（MCRs）将 PBA 基团引入聚合物结构中，开发了多功能 PBA-聚合物（MF-PBA-聚合物）。这些 MF-PBA-聚合物具有类似于传统 PBA-聚合物的特性；此外，当使用不同的 MCRs 时，它们还表现出额外的性质，如荧光、抗菌活性和抗氧化能力。在这篇综述中，总结了这些 MF-PBA-聚合物的制备方法，并讨论了使用不同 MCRs 引入到这些聚合物中的新性质/功能。讨论了这些 MF-PBA-聚合物作为荧光细胞抗凝剂、药物载体和功能性自修复水凝胶的凝胶剂的用途。此外，还讨论了它们在制备过程中遇到的挑战，并探讨了该领域的未来发展。
