Pan Guoying, Zhang Ji'aodi, Liang Yongping, Guo Baolin
Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Jul;54(4):726-730. doi: 10.12182/20230760206.
Diabetic chronic wounds entail enormous psychological and economic burdens on diabetic patients. Traditional types of wound dressings lack diversity in their functions and do not have sufficient adaptability to the wound environment, which makes it difficult to meet the complicated needs arising during the healing process when they are used. Stimuli-responsive hydrogels respond specifically to the special environment of the wound area, for example, temperature, pH, glucose, etc., and achieve on-demand release by loading active substances, which effectively promotes diabetic wound healing. Herein, based on the research progress in stimulus-responsive wound dressings in recent years and the relevant work of our research team, we summarized and discussed hydrogel wound dressings responsive to temperature, pH, glucose, reactive oxygen species, enzymes, and multiple stimuli. Based on the special physiological environment of diabetic wounds, hydrogels with single or multiple stimuli-responsive properties can be designed so that they can release drugs on demand and improve the microenvironment of the wound, thus meeting the specific needs of different stages of wound healing. Although stimuli-responsive hydrogels currently show excellent therapeutic potential, there is still room for further development-cells or cytokines loaded in wound dressings usually act only at specific healing stages and the timing needs to be precisely controlled in order to avoid counterproductive effects on wound healing. In addition, the construction of sensor-therapeutic integrated devices for real-time monitoring of wound biochemical indicators so that drugs are release on demand and with precision to promote wound healing is also one of the topics that deserve more attention from researchers.
糖尿病慢性伤口给糖尿病患者带来了巨大的心理和经济负担。传统类型的伤口敷料功能单一，对伤口环境的适应性不足，使用时难以满足愈合过程中出现的复杂需求。刺激响应性水凝胶对伤口区域的特殊环境，如温度、pH值、葡萄糖等有特异性响应，并通过负载活性物质实现按需释放，有效促进糖尿病伤口愈合。在此，基于近年来刺激响应性伤口敷料的研究进展以及我们研究团队的相关工作，我们总结并讨论了对温度、pH值、葡萄糖、活性氧、酶和多种刺激响应的水凝胶伤口敷料。基于糖尿病伤口的特殊生理环境，可以设计具有单一或多种刺激响应特性的水凝胶，使其能够按需释放药物并改善伤口微环境，从而满足伤口愈合不同阶段的特定需求。尽管刺激响应性水凝胶目前显示出优异的治疗潜力，但仍有进一步发展的空间——伤口敷料中负载的细胞或细胞因子通常仅在特定的愈合阶段起作用，且时间需要精确控制，以避免对伤口愈合产生适得其反的效果。此外，构建用于实时监测伤口生化指标的传感-治疗一体化装置，以便按需精确释放药物以促进伤口愈合，也是值得研究人员更多关注的课题之一。
