College of Chemistry & Materials Science, South-Central University for Nationalities, Wuhan, China.
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
Nat Prod Res. 2022 Mar;36(6):1522-1528. doi: 10.1080/14786419.2021.1897591. Epub 2021 Mar 10.
Four new resorcinol derivatives, namely (-)/(+)-xylarinig A (), as well as xylarinigs B () and C (), were isolated from the ethyl acetate extracts of the solid fermentation of . Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound is an optical mixture, and was resoluted into optical pure enatiomers (+)- and (-)- by chiral HPLC. The neuroprotective effects of - against the damage of PC12 cells induced by oxygen and glucose deprivation (OGD) were evaluated.
四种新的间苯二酚衍生物，即（-）/（+）-木藜芦醇 A ()、木藜芦醇 B () 和 C ()，从 的固体发酵的乙酸乙酯提取物中分离得到。它们的结构通过综合光谱分析结合电子圆二色性 (ECD) 计算确定。化合物 是一种光学混合物，通过手性 HPLC 分离为光学纯对映异构体 (+)-和 (-)-。评估了 - 对氧葡萄糖剥夺 (OGD) 诱导的 PC12 细胞损伤的神经保护作用。
